IgE-mediated occupational asthma from epoxy resin

International Archives of Allergy and Immunology
Timo HannuKristiina Alanko

Abstract

Epoxy resins (ERs) are used in paints and other protective coatings, including flooring materials. Bisphenol A diglycidyl ether (BADGE) ERs (BADGE ERs) account for about 75% of the ERs used world-wide. ERs can cause both immediate and delayed allergic reactions, but immediate reactions are rare. Occupational asthma (OA) was diagnosed on the basis of a specific challenge test combined with the patient's history of occupational exposure and respiratory symptoms. A 39-year-old nonsmoking construction worker experienced dyspnea when laying ER-containing floors, but not in other situations. He also presented skin symptoms. IgE-mediated allergy to BADGE ER could be verified with both serum IgE antibodies and skin prick tests. The specific bronchial challenge test with BADGE ER caused an immediate asthmatic reaction. On patch testing, a positive reaction was provoked by BADGE ER. This is the first study on a patient exposed to BADGE ER with IgE-mediated immediate OA, based on a positive inhalation challenge test. If work-related respiratory symptoms develop when handling ERs, the possibility of OA should be recognized.

Citations

Jul 24, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Stephen M BauerB Paige Lawrence
Nov 11, 2015·Clinical and Translational Science·Stella E HinesCecile S Rose
Jan 15, 2016·International Journal of Hygiene and Environmental Health·I-Jen WangCarl-Gustaf Bornehag
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Jan 13, 2012·American Journal of Industrial Medicine·V H ArrandaleD L Holness
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Feb 8, 2018·Allergy, Asthma & Immunology Research·Tien Jen LinI Jen Wang
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Oct 7, 2014·Journal of Occupational and Environmental Medicine·Susan Tarlo
Dec 28, 2018·European Journal of Medical Research·Mayumi TsujiToshihiro Kawamoto

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