PMID: 8939159Nov 1, 1996Paper

IgE reactivity against a cross-reactive allergen in crustacea and mollusca: evidence for tropomyosin as the common allergen

The Journal of Allergy and Clinical Immunology
P S LeungK H Chu

Abstract

Although cross-reactivity between mollusks and other crustaceans in shrimp-sensitive subjects has been reported, the mechanism of this allergenic cross-reactivity has not been studied in detail. To investigate this cross-reactivity in vitro, we have taken advantage of a complementary DNA that expresses tropomyosin, the immunodominant shrimp allergen. Serum IgE from nine patients with known anaphylaxis to shrimp and five normal volunteers were analyzed by immunoblotting against 13 distinct crustaceans and mollusks. As additional antigens, muscle preparations were isolated from grasshopper, cockroach, fruit fly, chicken, and mouse. Sera from all patients, but not control subjects, reacted specifically with a 38 kd protein in all crustaceans and mollusks studied. In addition, 8 of 9 sera from patients, but from none of the normal control subjects, recognized proteins of various other molecular weights among the mollusk extracts studied. The 38 kd protein was identified as tropomyosin and was shown to share immunodominant epitopes among all species of crustaceans and mollusks tested by specific absorption studies. Moreover, sera from all nine subjects with shrimp allergy demonstrated IgE reactivities against grasshopper, cockroach,...Continue Reading

References

Mar 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P S LeungM E Gershwin
Oct 1, 1991·Allergy·T CarrilloP Cabrera
Aug 1, 1987·The Journal of Allergy and Clinical Immunology·S B Lehrer, M L McCants
Aug 1, 1989·The Journal of Allergy and Clinical Immunology·V L KoshteR C Aalberse
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R L CoppelM E Gershwin
Jan 1, 1987·International Archives of Allergy and Applied Immunology·L HalmepuroS B Lehrer
Jan 1, 1985·International Archives of Allergy and Applied Immunology·S B LehrerJ E Salvaggio
Oct 1, 1995·International Archives of Allergy and Immunology·A M WittemanR C Aalberse
Sep 1, 1994·International Archives of Allergy and Immunology·C B DaulS B Lehrer
Nov 1, 1994·The Journal of Allergy and Clinical Immunology·P S LeungM E Gershwin
Sep 1, 1994·International Archives of Allergy and Immunology·A M WittemanR C Aalberse
Sep 1, 1993·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J J MusmandS B Lehrer

❮ Previous
Next ❯

Citations

Mar 20, 2002·Current Allergy Reports·L G Wild, S B Lehrer
Jan 22, 2005·Current Allergy and Asthma Reports·Laurianne G Wild, Samuel B Lehrer
Nov 3, 2011·Clinical Reviews in Allergy & Immunology·Parvaneh Hajeb, Jinap Selamat
Sep 3, 2013·Human Immunology·Eugene V RavkovJulio C Delgado
Jan 10, 2004·The Journal of Allergy and Clinical Immunology·Shao-Hsuan KaoLu-Ping Chow
Apr 7, 2006·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·UNKNOWN American College of Allergy, Asthma, & Immunology
Jan 11, 2001·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·G Reese, S B Lehrer
Jan 11, 2001·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·D W Goetz, B A Whisman
Dec 3, 1999·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·R AyusoG Reese
Jan 30, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Raymond J Mullins, Robert Heddle
Feb 19, 2002·Trends in Parasitology·María Teresa AudicanaMalcolm W Kennedy
Aug 11, 2007·Food Additives and Contaminants·Kanna MotoyamaKazuo Shiomi
Nov 24, 1998·Allergy·P V Subba RaoK A Ganesh
Aug 21, 2001·Occupational and Environmental Medicine·M F JeebhayA L Lopata
Oct 4, 2007·International Archives of Allergy and Immunology·Shigeru NakanoToshihiro Yamada
Jan 22, 2008·International Archives of Allergy and Immunology·Kazuo ShiomiKuniyoshi Shimakura
Jan 1, 2011·Clinical and Translational Allergy·Chee K Woo, Sami L Bahna
Apr 9, 2009·Bioscience, Biotechnology, and Biochemistry·Ayumi KunimotoMasumi Kimoto
Apr 1, 2011·Allergy & Rhinology·Faria KhanCarla McGuire Davis
Jul 3, 2010·Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan·Kosuke SeikiReiko Teshima
Sep 10, 2010·Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan·Kazuo Shiomi
Dec 18, 2012·Clinical Reviews in Allergy & Immunology·Nicki Y H LeungPatrick S C Leung
Feb 15, 2016·Current Allergy and Asthma Reports·Ashley M Kazatsky, Robert A Wood
Apr 18, 2002·Allergologia et immunopathologia·M C Moreno EscobosaB Bartolomé Zavala
Feb 17, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yuan-Yuan HuangMin-Jie Cao
Sep 2, 2008·The Journal of Allergy and Clinical Immunology·Rosalía AyusoKirsten Beyer
Feb 27, 2007·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Yota SumaKazuo Shiomi
Aug 14, 2009·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Roshni M Kandyil, Carla M Davis
Nov 7, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J VillacisS B Lehrer
May 24, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·O JirapongsananurukP Vichyanond
Nov 28, 2012·Journal of the Science of Food and Agriculture·Hajime MitaKazuo Shiomi
Jul 1, 2014·Molecular Nutrition & Food Research·Cristina GámezVictoria del Pozo
Apr 24, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A L LopataS B Lehrer
May 30, 2014·Clinical Reviews in Allergy & Immunology·María PedrosaSantiago Quirce
Aug 15, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K MotoyamaK Shiomi
Apr 4, 2016·Current Allergy and Asthma Reports·David R Stukus, Irene Mikhail
Apr 5, 2016·Contact Dermatitis·Suzana Ljubojević HadžavdićMirna Bradamante

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.