IgE responses to multiple allergen components among school-aged children in a general population birth cohort in Tokyo

The World Allergy Organization Journal
Kiwako Yamamoto-HanadaYukihiro Ohya

Abstract

Response patterns to allergen components among Japanese children have not been studied extensively. Our aim was to examine the differences in sensitization patterns at ages 5 years and 9 years to identify longitudinal changes in the degree and patterns of sensitization in a birth cohort of Japanese children. Our study enrolled 984 children at aged 5 years between 2008 and 2010, and 729 children aged 9 years between 2012 and 2014. Allergic diseases were assessed using the ISAAC and UK Working Party's Diagnostic Criteria. Serum-specific IgE titers to allergen components were measured by multiplex array ImmunoCAP ISAC when the children were aged 5 and 9 years. Principal component analysis (PCA) was performed to characterize IgE sensitization to allergen components. The prevalence of allergic rhinitis increased considerably over time (10.6%-31.2%). Furthermore, the sensitization prevalence to allergen-specific IgE (sIgE) also increased from 57.8% at age 5 years to 74.8% at age 9 years. IgE sensitization prevalence to Der f 1 (mites) was 42.1% at age 5 years and 54.3% at age 9 years. Furthermore, children were highly sensitized to Cry j 1 (Japanese cedar) (32.8% at age 5 years and 57.8% at age 9 years). Principle component analysis ...Continue Reading

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Citations

Aug 7, 2020·Biosensors & Bioelectronics·Salvador MasÁngel Maquieira
Jan 15, 2021·The Journal of Allergy and Clinical Immunology·Ann-Marie M SchoosMagnus P Borres
Feb 28, 2021·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Kiwako Yamamoto-HanadaUNKNOWN Japan Environment and Children’s Study (JECS) Group
May 9, 2021·Allergology International : Official Journal of the Japanese Society of Allergology·Toshihiro Osada, Mitsuhiro Okano

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Methods Mentioned

BETA
chip
PCA

Software Mentioned

R

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