IgE-Selective Immunoadsorption for Severe Atopic Dermatitis

Frontiers in Medicine
Michael KasperkiewiczEnno Schmidt

Abstract

Recent reports proposed the application of immunoadsorption (IA) for patients with recalcitrant atopic dermatitis (AD) and high-serum IgE levels. However, experience with this novel treatment approach, especially with the newly available IgE-specific adsorber, is limited and recommendation for its use in clinical practice awaits evidence from more studies. Patients with severe AD (SCORAD ≥ 60) and total serum IgE levels ≥750 kU/L were included in this study. The treatment protocol consisted of two cycles of five consecutive treatments with IgE-selective IA 3 weeks apart. Ten patients were enrolled and four patients completed the study. The mean SCORAD was significantly improved by up to 43% within a few weeks and until the end of a 6-month follow-up period, with 50% of patients achieving an at least 50% individual reduction of the baseline SCORAD. Each IA cycle induced a temporal average decrement of total serum levels of IgE, IgM, IgA, and IgG by 92, 43, 38, and 35%, respectively. Except for one case ofStaphylococcus aureussepticemia, no major adverse events occurred. Although limited by a considerable withdrawal rate, our observations strengthen our and other recent results further suggesting that IgE-selective IA is an effec...Continue Reading

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Citations

Nov 23, 2019·Journal of Clinical Apheresis·Damian MeyersburgChristoph Grabmer
Sep 26, 2019·Frontiers in Immunology·Lennart M Roesner, Thomas Werfel
Mar 10, 2018·Frontiers in Immunology·Michael KasperkiewiczDetlef Zillikens
Dec 7, 2018·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·Franziska HübnerEnno Schmidt
Oct 23, 2019·Frontiers in Immunology·Kelly N MessinghamJanet A Fairley
Apr 6, 2021·The World Allergy Organization Journal·Andreas WollenbergSlawomir Lazarewicz

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Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

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