Jan 1, 1977

IgE-type antibodies to Ascaris antigens in man

International Archives of Allergy and Applied Immunology
M TsujiT Toshida

Abstract

IgE antibodies to Ascaris antigens were detected by radioallergosorbent test (RAST) in the serum obtained from a person experimentally sensitized with Ascaris suum antigens prepared from the body fluid of worms. This serum passively sensitized human skin in vitro and histamine release from the sensitized skin was observed by challenge with antigens. The allergenicity of A. suum antigens was present over a very broad spectrum of molecular size. The present results suggest that specific IgE antibodies to Ascaris antigens might be in Ascaris-infected patients and allergic symptoms which belong to type 1 reaction might be mediated by IgE in these patients.

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Mentioned in this Paper

Ascaris suum
Allergic Symptom
Antigenic Specificity
Helminths
Radioallergosorbent Test
Antibody Formation
Immunoglobulin E
Ascaris
Antigens
Antigen-Antibody Reactions

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