IgE/FcεRI-Mediated Antigen Cross-Presentation by Dendritic Cells Enhances Anti-Tumor Immune Responses

Cell Reports
Barbara PlatzerEdda Fiebiger

Abstract

Epidemiologic studies discovered an inverse association between immunoglobulin E (IgE)-mediated allergies and cancer, implying tumor-protective properties of IgE. However, the underlying immunologic mechanisms remain poorly understood. Antigen cross-presentation by dendritic cells (DCs) is of key importance for anti-tumor immunity because it induces the generation of cytotoxic CD8+ T lymphocytes (CTLs) with specificity for tumor antigens. We demonstrate that DCs use IgE and FcεRI, the high-affinity IgE receptor, for cross-presentation and priming of CTLs in response to free soluble antigen at low doses. Importantly, IgE/FcεRI-mediated cross-presentation is a distinct receptor-mediated pathway because it does not require MyD88 signals or IL-12 induction in DCs. Using passive immunization with tumor antigen-specific IgE and DC-based vaccination experiments, we demonstrate that IgE-mediated cross-presentation significantly improves anti-tumor immunity and induces memory responses in vivo. Our findings suggest a cellular mechanism for the tumor-protective features of IgE and expand the known physiological functions of this immunoglobulin.

References

Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·B BettlerH Hofstetter
Oct 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·P R Scholl, R S Geha
Dec 20, 2000·The Journal of Experimental Medicine·J M den HaanM J Bevan
Jan 6, 2006·Annals of the New York Academy of Sciences·Ines Mende, Edgar G Engleman
May 12, 2007·European Journal of Immunology·Peter DubskyA Karolina Palucka
Sep 15, 2007·Nature Reviews. Immunology·Paul J TackenCarl G Figdor
Sep 18, 2007·Immunity·Guillaume HoeffelConcepción Marañón
Aug 2, 2008·Allergy·E Jensen-JarolimH Gould
Oct 30, 2008·European Journal of Immunology·Kotaro SasakiWalter J Storkus
Dec 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ronald BackerJoke M M den Haan
Jun 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Kristi BakerRichard S Blumberg
Sep 17, 2011·Immunology Letters·Barbara PlatzerEdda Fiebiger
Dec 1, 2011·Cancer Immunology, Immunotherapy : CII·Tracy R DanielsManuel L Penichet
Dec 6, 2011·Cancer Immunology, Immunotherapy : CII·Sophia N KaragiannisHannah J Gould
Mar 3, 2012·Journal of Clinical Immunology·Caroline StaffGustav J Ullenhag
Mar 23, 2012·Nature Reviews. Cancer·Karolina Palucka, Jacques Banchereau
May 9, 2012·Nature Medicine·Stephen J Galli, Mindy Tsai
Jul 14, 2012·Nature Reviews. Immunology·Olivier P JoffreSebastian Amigorena
May 30, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yusuke TomitaYasuharu Nishimura
Oct 1, 2013·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D H JosephsS N Karagiannis
Nov 12, 2013·Immunity·Thomas MarichalStephen J Galli
Jan 22, 2014·Nature Reviews. Immunology·Martin GuilliamsBart N Lambrecht
Feb 22, 2014·Current Opinion in Immunology·Verena Schuette, Sven Burgdorf
Apr 18, 2014·Science Translational Medicine·Madhav V DhodapkarTibor Keler
Apr 20, 2014·Frontiers in Immunology·Barbara PlatzerEdda Fiebiger
Oct 11, 2014·Journal of Dermatological Science·Muzlifah HaniffaLaura Jardine

❮ Previous
Next ❯

Citations

May 27, 2015·PloS One·Dhammika H M L P NavarathnaDavid D Roberts
Oct 25, 2016·The Journal of Investigative Dermatology·Patrick M BrunnerUNKNOWN Councilors of the International Eczema Council
Jan 9, 2018·Oncoimmunology·Gilda VarricchiGiovanna Schiavoni
Aug 11, 2017·Cancer Immunology, Immunotherapy : CII·Mieke Van HemelrijckSabine Rohrmann
Sep 19, 2017·Allergy·E Jensen-JarolimS N Karagiannis
Apr 28, 2017·Frontiers in Immunology·Gilda VarricchiFrancescopaolo Granata
Jun 7, 2019·F1000Research·Andrea J LukerRebecca K Martin
Aug 28, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elisa A NigroLuca Vangelista
Sep 24, 2019·Antibodies·Brian J SuttonSophia N Karagiannis
Oct 22, 2020·Antibodies·Jitesh ChauhanHeather J Bax
Nov 6, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Vincent BernardHector A Alvarez
Dec 17, 2020·Expert Opinion on Investigational Drugs·Juan Wang, Sumera Ilyas
Nov 19, 2020·Cancers·Mano NakamuraSophia N Karagiannis
Mar 6, 2021·The World Allergy Organization Journal·Denisa FerastraoaruErika Jensen-Jarolim
Nov 7, 2020·Clinical and Experimental Immunology·N VukovicD M W Zaiss
Oct 10, 2021·Molecular Cancer Therapeutics·Spas Dimitrov MarkovKamiya Mehla

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

Basophils

Basophils are myeloid cells with a high affinity IgE receptor and is involved in inflammatory responses during allergy. Discover the latest research on Basophils here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.