IGF-1, IGFBP-3 and ALS in adult patients with chronic kidney disease

Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society
Julia LepeniesMarcus Quinkler

Abstract

Insulin-like growth factor I (IGF-1) is for the most part bound in a ternary complex with IGF-binding protein-3 (IGFBP-3) and acid-labile subunit (ALS). This ternary complex is a storage form of IGF-1 in blood and passes not through the renal glomerulus. Little information is available in regard to the components of the ternary complex in adult renal disease. To investigate levels of serum IGF-1, IGFBP-3 and ALS in relation to renal function and extent of proteinuria. We measured IGF-1, IGFBP-3 and ALS concentrations in 137 patients who were investigated due to proteinuria and/or haematuria and/or renal impairment. The patients received renal biopsies and the histological diagnosis was documented. Urinary albumin excretion and relevant clinical parameter were evaluated. IGF-1 showed a highly positive correlation to IGFBP-3 and ALS, and the latter to IGFBP-3. IGF-1, IGFBP-3 and ALS decreased with increasing age. IGF-1 and IGFBP-3 showed no significant change depending on the creatinine clearance. However, ALS decreased with decreasing renal function. In patients with heavy proteinuria ALS levels, but not IGF-1 and IGFBP-3 levels, decreased significantly. Patients with chronic ischaemic renal damage and diabetic glomerulopathy sh...Continue Reading

References

Jul 1, 1991·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·W F BlumO Mehls
Feb 1, 1995·Endocrine Reviews·J I Jones, D R Clemmons
May 1, 1996·The Journal of Clinical Endocrinology and Metabolism·D Y LeeJ S Kim
Apr 1, 1996·Kidney International·R RabkinN Gesundheit
Jan 1, 1995·Progress in Growth Factor Research·P Bang
Sep 1, 1996·Endocrinology and Metabolism Clinics of North America·P F Collett-Solberg, P Cohen
Jun 19, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R Hirschberg, S Adler
Oct 29, 2000·Journal of the American Society of Nephrology : JASN·John HaylorA Meguid El Nahas
Feb 19, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Anne K Berfield, Christine K Abrass
Aug 2, 2002·Breast Cancer Research and Treatment·Pamela J GoodwinNicky Hood
Sep 18, 2002·Kidney International·Anne K BerfieldChristine K Abrass
Aug 7, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Feng Dong, Jun Ren
Jul 3, 2004·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Ralph Rabkin, Franz Schaefer
Jan 30, 2008·Endocrinology and Metabolism Clinics of North America·Anat Ben-Shlomo, Shlomo Melmed
Apr 29, 2008·The Tohoku Journal of Experimental Medicine·Bilal YildizOmer Colak

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Citations

Nov 30, 2011·Current Opinion in Nephrology and Hypertension·Leon A Bach
Aug 26, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Leon A Bach, Lorna J Hale

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