IGF-1 protects dopamine neurons against oxidative stress: association with changes in phosphokinases

Experimental Brain Research
Amina El AyadiAmanda D Smith

Abstract

Insulin-like growth factor-1 (IGF-1) is an endogenous peptide transported across the blood brain barrier that is protective in several brain injury models, including an acute animal model of Parkinson's disease (PD). Motor deficits in PD are due largely to the progressive loss of nigrostriatal dopaminergic neurons. Thus, we examined the neuroprotective potential of IGF-1 in a progressive model of dopamine deficiency in which 6-hydroxydopamine (6-OHDA) is infused into the striatum. Rats received intrastriatal IGF-1 (5 or 50 µg) 6 h prior to infusion of 4 µg 6-OHDA into the same site and were euthanized 1 or 4 weeks later. Both concentrations of IGF-1 protected tyrosine hydroxylase (TH) immunoreactive terminals in striatum at 4 weeks but not at 1 week, indicating that IGF-induced restoration of the dopaminergic phenotype occurred over several weeks. TH-immunoreactive cell loss was only attenuated with 50 µg IGF-1. We then examined the effect of striatal IGF-1 on the Ras/ERK1/2 and PI3K/Akt pathways to ascertain whether their activation correlated with IGF-1-induced protection. Striatal and nigral levels of phospho-ERK1/2 were maximal 6 h after IGF-1 infusion and, with the exception of an increase in nigral pERK2 at 48 h, returned...Continue Reading

References

Jan 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·P RotweinJ E Krause
Aug 27, 1993·Annals of the New York Academy of Sciences·D LeRoithC T Roberts
May 15, 1993·The Journal of Comparative Neurology·D C German, K F Manaye
Jul 1, 1996·Experimental Neurology·W M ZawadaC R Freed
Jul 1, 1997·The EMBO Journal·H AberleR Kemler
Aug 26, 1998·Neurology·O Hornykiewicz
Oct 12, 2000·Neuroendocrinology·W Pan, A J Kastin
Oct 14, 2000·Experimental Neurology·D W HowellsG A Donnan
Jan 15, 2003·Neurology·J G NuttUNKNOWN ICV GDNF Study Group. Implanted intracerebroventricular. Glial cell line-derived neurotrophic factor
Feb 15, 2003·Cellular and Molecular Neurobiology·Mariana AlonsoJorge H Medina
Mar 26, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Gloria Patricia Cardona-GómezLuis M Garcia-Segura
Aug 21, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gina M LeinningerEva L Feldman
Feb 14, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Todd B ShererJ William Langston
Mar 3, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Marcello MaggioE Jeffrey Metter
Mar 8, 2006·The European Journal of Neuroscience·Guido C KoopmansFrank P T Hamers
Oct 13, 2006·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·F YaghmaieP S Timiras
Nov 26, 2009·The International Journal of Biochemistry & Cell Biology·Ki Cheon KimJin Won Hyun
Apr 24, 2010·Cellular and Molecular Neurobiology·Manami AbeTsutomu Araki

❮ Previous
Next ❯

Citations

Jan 17, 2019·Journal of Tissue Engineering and Regenerative Medicine·Begoña CastroTeodoro Palomares
Jun 25, 2020·Journal of Clinical Medicine·Bianca MarchettiNunzio Iraci
Jul 9, 2020·Addiction Biology·Antonio Jesús López-GamberoJuan Suárez
Sep 1, 2020·American Journal of Physiology. Endocrinology and Metabolism·Xiao Wen WangWen-Fang Chen
Feb 22, 2017·The Journal of Gene Medicine·Yousheng XiaoPingyi Xu
Mar 27, 2020·Frontiers in Systems Neuroscience·Robert D Black, Lesco L Rogers
Jun 12, 2018·Restorative Neurology and Neuroscience·Diana M SamaKathryn E Saatman
Mar 20, 2019·Physiology International·P D Loprinzi
Feb 28, 2019·Proceedings of the National Academy of Sciences of the United States of America·Alessandro PristeràSiew-Lan Ang
Jun 3, 2021·International Journal of Molecular Sciences·Banseok LeeKyoung Sang Cho
Oct 9, 2019·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Hua-Bin ZhangSong-Sheng Shi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.