IGF-Binding Protein 2 - Oncogene or Tumor Suppressor?

Frontiers in Endocrinology
Adam Pickard, Dennis J McCance

Abstract

The role of insulin-like growth factor binding protein 2 (IGFBP2) in cancer is unclear. In general, IGFBP2 is considered to be oncogenic and its expression is often observed to be elevated in cancer. However, there are a number of conflicting reports in vitro and in vivo where IGFBP2 acts in a tumor suppressor manner. In this mini-review, we discuss the factors influencing the variation in IGFBP2 expression in cancer and our interpretation of these findings.

References

Oct 11, 1991·The Journal of Clinical Endocrinology and Metabolism·D R ClemmonsW H Busby
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·W ZumkellerM A Preece
May 15, 1994·International Journal of Cancer. Journal International Du Cancer·F el AtiqG Pommier
Jan 10, 1998·The Journal of Biological Chemistry·Y YamanakaY Oh
Sep 15, 1999·Journal of Korean Medical Science·D Y LeeY C Lee
Oct 6, 1999·Current Biology : CB·D N SheltonW D Funk
Sep 21, 2000·Journal of the National Cancer Institute·H Yu, T Rohan
Sep 22, 2000·The Journal of Clinical Endocrinology and Metabolism·A G RenehanS M Shalet
Feb 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Shahrokh F ShariatKevin M Slawin
Jul 20, 2002·The Journal of Steroid Biochemistry and Molecular Biology·Svein I HellePer E Lønning
Dec 6, 2002·Endocrine Reviews·Sue M Firth, Robert C Baxter
Apr 10, 2003·Virchows Archiv : an International Journal of Pathology·Elin RichardsenChrister Busch
Jun 10, 2003·International Journal of Cancer. Journal International Du Cancer·Lital Keinan-BokerPetra H M Peeters
Jan 13, 2004·The Journal of Clinical Endocrinology and Metabolism·D GunnellJ M P Holly
Mar 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sally Baron-HayCarolyn Scott
Jun 3, 2004·Journal of Molecular Endocrinology·B S SchüttM W Elmlinger
Jul 2, 2004·Nature Reviews. Cancer·Michael N PollakSusan E Hankinson
Feb 22, 2005·Neoplasia : an International Journal for Oncology Research·Dominique B HoelzingerMichael E Berens
Mar 26, 2005·Journal of Clinical Pathology·L-T BusundH Stalsberg
May 25, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Tetsuhiro ChibaHiromitsu Saisho
Aug 2, 2005·Pediatric Research·Anne ChettyHeber C Nielsen
Sep 13, 2005·Biochemical and Biophysical Research Communications·Randy J LevittMichael Pollak
Jan 18, 2006·Journal of Pediatric Surgery·John A SandovalLinda H Malkas

❮ Previous
Next ❯

Citations

May 25, 2016·BMC Pulmonary Medicine·J GuiotR Louis
Jul 19, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Tao PengLing Zuo
Jan 25, 2019·Journal of Cellular and Molecular Medicine·Raghu BhushanPeter N Robinson
Sep 12, 2020·Cancers·Iwona SidorkiewiczAdam Krętowski
Jul 15, 2017·In Vitro Cellular & Developmental Biology. Animal·Jiao ZhaoZhen Li
Aug 18, 2020·Journal of Neuro-oncology·Brijesh Kumar Verma, Paturu Kondaiah
Apr 23, 2017·The Journal of Biological Chemistry·James M DolezalEdward V Prochownik
Mar 7, 2020·Frontiers in Oncology·Roberta Fajka-BojaRóbert L Katona
Jun 3, 2021·International Journal of Molecular Sciences·Alejandro Álvarez-ArtimeJuan Carlos Mayo
Dec 25, 2019·Experimental and Molecular Pathology·Gurjeet KaurYung Jen Lee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.