IGF-binding protein mRNAs in the human fetus: tissue and cellular distribution of developmental expression

Hormone Research
V K HanK Nygard

Abstract

Insulin-like growth factors (IGF-I and IGF-II) are synthesized by most embryonic and fetal tissues, and regulate cellular growth and differentiation as autocrine/paracrine factors. A family of six IGF-binding proteins (IGFBPs) modulate IGF biological actions as both negative (inhibitory) and positive (potentiating) modulators. To determine the tissue distribution of IGFBP mRNA expression, we performed Northern blot analysis and in situ hybridization of human fetal tissues during gestational ages 10-16 weeks (n = 8). IGFBP-1 mRNA was expressed only in the liver, whereas other IGFBP mRNAs were expressed in variable abundance in every tissue examined. IGFBP-2 mRNA was expressed in moderate abundance in every tissue with the highest level observed in the liver; IGFBP-3 mRNA was expressed most abundantly in the skin, muscle and heart; IGFBP-4 mRNA was expressed in moderate abundance equally in all tissues; IGFBP-5 mRNA was expressed most abundantly in the skin, muscle and stomach, and IGFBP-6 mRNA was expressed in low abundance in all tissues. Notable exceptions were that liver expressed little or no IGFBP-4, -5 and -6 mRNAs, spleen and thymus expressed low levels of IGFBP-5 mRNA, and brain expressed little or no IGFBP-5 and IGFBP-6...Continue Reading

Citations

Jun 24, 2011·The Journal of Biological Chemistry·Byoungjae KimDaniel S Greenspan
Sep 23, 2010·Cancer Prevention Research·Pamela Jo HarrisS Percy Ivy
Jan 7, 2016·Molecular and Cellular Endocrinology·Niyati MalkaniMadhulika B Gupta
Mar 14, 2012·Molecular and Cellular Endocrinology·Zhuo LiFrédéric Picard
Feb 11, 2010·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·David PhangXuezhong Qin
Nov 3, 2015·Best Practice & Research. Clinical Endocrinology & Metabolism·Michael B Ranke
Dec 24, 2005·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·T Y LeungT K Lau
May 10, 2015·Molecular and Cellular Endocrinology·Niyati MalkaniMadhulika B Gupta
Feb 13, 2001·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·D ChamberyS Babajko
Feb 16, 2015·Journal of Cell Communication and Signaling·Madhulika B Gupta
Jan 28, 2004·Journal of Cutaneous Pathology·Huamin WangVictor G Prieto
Nov 27, 2018·Biology of Reproduction·Madhulika B Gupta, Thomas Jansson
Aug 21, 2018·The Journal of Clinical Endocrinology and Metabolism·Madhulika B GuptaThomas Jansson
Jan 26, 2006·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·T Y LeungT K Lau
Jan 26, 2006·Endocrine Reviews·Vanessa E MurphyVicki L Clifton
Mar 21, 2012·Nature Reviews. Neuroscience·Ana M Fernandez, Ignacio Torres-Alemán
Jul 29, 2003·Journal of Cardiovascular Pharmacology·Shoko MiuraKunio Shirato
Sep 1, 2005·Endocrine Reviews·V C RussoG A Werther
Aug 4, 2020·American Journal of Physiology. Endocrinology and Metabolism·Jenica H KakadiaMadhulika B Gupta
Nov 14, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·C A ShoubridgeL C Read
Jun 2, 2020·Frontiers in Cell and Developmental Biology·Shailly Varma ShrivastavAnuraag Shrivastav
May 13, 2005·Mechanisms of Ageing and Development·John PapaconstantinouDavid E Harrison
Jul 28, 2021·Molecular and Cellular Endocrinology·Allan W ChenMadhulika B Gupta

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.