PMID: 16625852Apr 22, 2006Paper

IGF-I and mortality in patients with acromegaly

Journal of Endocrinological Investigation
Christian J Strasburger

Abstract

There are several studies in the literature relating mortality in patients with acromegaly to GH levels either as random samples or as a mean of several spontaneous samples or GH nadir after oral glucose load. Fewer articles have been published until now on the relationship between IGF-I and mortality, with several of these studies reporting a clear association, while two databases did not find an association between mortality and IGF and have instead shown an interrelationship between mortality and GH levels. These latter studies report databases in which fewer individuals have been sampled for IGF-I than for GH. Moreover, reliable immunoassays for GH measurement have existed for almost 20 yr more than immunoassays for IGF-I. Since between-method results diverge for both GH and IGF-I, it appears desirable to have levels of both biochemical markers measured in the follow-up of acromegaly, preferably in a central laboratory setting. Only by this prospective effort, it will be possible in the future to evaluate the relative ability of IGF-I and GH in predicting the residual risk of patients with acromegaly in relation to mortality, but also to co-morbidities.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved