PMID: 15226603Jul 1, 2004Paper

IGF-I Overexpression causes fetal loss during placentation in mice

The Journal of Reproduction and Development
Orie NakamuraYasuo Kiso

Abstract

To understand the role of IGF-I in murine pregnancy, we studied the reproductive performance of IGF-I overexpressed mice. Fetal loss occurred only in the transfected uterine horn during day 10-15 of pregnancy. The placenta appeared healthy until Day 10 of pregnancy. From day 12, the decidua basalis of the transfected horn increased in thickness. The vascular lumen was expanded, and most of embryos were dead. Uterine natural killer cells did not undergo apoptosis from day 10 to day 15 when they usually go through apoptosis. Thus, it is likely that IGF-I plays a role in the decidual formation through regulation of uNK cells. This is the first report to demonstrate that IGF-I overexpression can cause fetal loss during murine placentation.

References

Mar 1, 1991·American Journal of Reproductive Immunology : AJRI·L M ZhengJ D Young
Feb 5, 1998·The Journal of Veterinary Medical Science·Y KisoF Sasaki
May 9, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·T G Burnett, J S Hunt
Nov 15, 2000·American Journal of Reproductive Immunology : AJRI·V Del GobboM G Premrov
Feb 24, 2001·The Journal of Veterinary Medical Science·Y NambaY Kiso

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Citations

Feb 14, 2013·Nature Communications·Fang NiHaiming Wei
Mar 23, 2005·The Journal of Reproduction and Development·Ken KusakabeYasuo Kiso
Jun 2, 2011·The Journal of Veterinary Medical Science·Masato HiyamaYasuo Kiso
Feb 25, 2006·Micron : the International Research and Review Journal for Microscopy·Berthold HuppertzMaria Kokozidou
May 8, 2009·The Journal of Veterinary Medical Science·Thanmaporn PhichitrasilpYasuo Kiso
Jan 24, 2019·American Journal of Physiology. Cell Physiology·Yalan XuXiaohong Zhang

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