PMID: 7545402Jun 1, 1995Paper

IGF, type I IGF receptor and IGF-binding protein mRNA expression in the developing mouse lung

Journal of Molecular Endocrinology
A G SchullerS L Drop

Abstract

The IGFs are important mitogens involved in lung growth and development. The regulation of IGF action depends not only on the expression of IGFs and IGF receptors, but also on the modulation of IGF activity by IGF-binding proteins (IGFBPs). In this study, we describe the mRNA expression of IGF-I, IGF-II, type I IGF receptor, IGFBP-2, IGFBP-4 and IGFBP-5 during mouse lung development as studied by in situ hybridization techniques. The IGF, type I IGF receptor and IGFBP-2, -4 and -5 genes were expressed in developing lung as early as embryonal day 12.5. Expression of IGFBPs-1, -3 and -6 was below detection. IGF and IGFBP-2 mRNAs were expressed both in mesenchymal and epithelial cells. Type I IGF receptor transcripts were also observed throughout the developing lung, with the exception of the epithelial cells of the bronchi after embryonal day 15. Furthermore, mRNA expression of IGFBPs-4 and -5 was noted in neighbouring cell types, and after embryonal day 15, co-expression of the type I IGF receptor and IGFBP-4 transcripts was detected. The observed expression patterns imply that the IGFBP-2, -4 and -5 genes are differentially regulated during embryonic development and suggest that each may have a discrete function. A possible rol...Continue Reading

Citations

Mar 8, 2000·Mechanisms of Development·D WarburtonW V Cardoso
Jun 3, 2006·Genome Research·Matthew F RuddUNKNOWN GELCAPS Consortium
May 6, 2006·Reproductive Biology and Endocrinology : RB&E·Marc SimardYves Tremblay
May 5, 2010·Journal of Pediatric Surgery·Elke RuttenstockPrem Puri
Jun 7, 2008·Animal Reproduction Science·L ZhangN Li
Mar 25, 2011·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Elke RuttenstockPrem Puri
Oct 17, 1998·Pediatric Pulmonology·H IJsselstijn, D Tibboel
May 13, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Nuria Moreno-BarriusoJosé G Pichel
Jul 7, 1999·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·D WarburtonK Anderson
Sep 9, 2006·Endocrinology·Delia SilvaMary Frances Lopez

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