IGF2BP1 harbors prognostic significance by gene gain and diverse expression in neuroblastoma

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Jessica L BellStefan Hüttelmaier

Abstract

Chromosomal 17q21-ter gain in neuroblastoma is both a common and prognostically significant event. The insulin-like growth factor-2 mRNA-binding protein 1 (IGF2BP1) gene is located near the proximal edge of this region. Here, its prognostic value is evaluated in neuroblastoma. The mRNA expression of IGF2BP family members was first evaluated by microarray data sets. In addition, in a separate cohort of 69 tumors, IGF2BP1 gene copy number, mRNA, and protein abundance were determined and compared with clinical parameters. In two independent microarray data sets, 77% to 100% of tumors had substantial IGF2BP1 mRNA levels measured. High IGF2BP1 transcript abundance was significantly associated with stage 4 tumors (P < .001) and decreased patient survival (P < .001). IGF2BP1 was also associated with MYCN gene amplification and MYCN mRNA abundance. In the 69 neuroblastoma samples, IGF2BP1 DNA copy number (increased in 84% of tumors), mRNA, and protein abundance were significantly higher in stage 4 compared with stage 1 tumors. Importantly, IGF2BP1 protein levels were associated with lower overall patient survival (P = .012) and positively correlated with MYCN mRNA, even when excluding MYCN-amplified tumors. Moreover, IGF2BP1 clearly af...Continue Reading

References

Sep 1, 1989·The Journal of Clinical Investigation·O M El-BadryM A Israel
Jun 24, 1999·The New England Journal of Medicine·N BownN Van Roy
Jul 24, 2001·Medical and Pediatric Oncology·N BownUNKNOWN U.K. Cancer Cytogenetics Group and the U.K. Children's Cancer Study Group
Dec 1, 2001·Journal of Clinical Pathology·N Bown
Feb 19, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Katleen De PreterJo Vandesompele
Jul 20, 2002·Cancer Letters·Frank Westermann, Manfred Schwab
Jan 18, 2003·International Journal of Cancer. Journal International Du Cancer·Panayotis IoannidisTheoni Trangas
Jan 20, 2004·Cancer Research·Charles R TessierJeff Ross
Feb 14, 2007·Haematologica·Yasodha NatkunamIzidore S Lossos
Apr 17, 2008·Cancer Research·Benjamin BoyerinasMarcus E Peter
Sep 4, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shailendra Kapoor
Nov 26, 2008·RNA·Doreen WeidensdorferStefan Hüttelmaier
Jun 19, 2010·The New England Journal of Medicine·John M Maris
Oct 26, 2010·Human Pathology·Jennifer J Findeis-Hosey, Haodong Xu
May 28, 2011·International Journal of Cancer. Journal International Du Cancer·Benjamin BoyerinasMarcus E Peter
Jan 27, 2012·Genes & Development·Nadine StöhrStefan Hüttelmaier
Oct 9, 2012·Nature Genetics·Jan J MolenaarJohannes H Schulte
Oct 17, 2012·Cellular and Molecular Life Sciences : CMLS·Jessica L BellStefan Hüttelmaier
Jan 22, 2013·Nature Genetics·Trevor J PughJohn M Maris
May 25, 2013·Nature Reviews. Cancer·Nai-Kong V Cheung, Michael A Dyer
Jan 7, 2014·Expert Opinion on Therapeutic Targets·Garrett M BrodeurVenkatadri Kolla
Jan 8, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Tony GutschnerSven Diederichs
Jul 30, 2014·Seminars in Cancer Biology·Marcell LedererStefan Hüttelmaier

❮ Previous
Next ❯

Citations

Jun 12, 2012·Translational Research : the Journal of Laboratory and Clinical Medicine·Kristine M WylieGregory A Storch
Feb 2, 2017·Cell Reports·Giuseppe NicastroAndres Ramos
Nov 21, 2017·Nucleic Acids Research·Iva NikolicAlexander Swarbrick
Jun 30, 2018·Journal of Hematology & Oncology·Xinwei HuangXiangyang Kong
Apr 7, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Run ShiLin Xu
Mar 17, 2020·Cancer Biomarkers : Section a of Disease Markers·Zhichao WangDayun Sui
Jul 28, 2020·International Journal of Molecular Sciences·Jessica L BellStefan Hüttelmaier
Jul 29, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jacob HaaseStefan Hüttelmaier
Jul 28, 2019·Nature Communications·Matthew WongTao Liu
May 16, 2020·International Journal of Molecular Sciences·Konstantin SchuschelJessica I Hoell
Aug 25, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Simon LabanJulia Butt
Mar 22, 2019·Cancer Research·Qing LanTao Liu
Apr 9, 2021·Frontiers in Molecular Biosciences·Markus GlaßStefan Hüttelmaier
May 25, 2021·Frontiers in Oncology·Danny MisiakStefan Hüttelmaier
Jul 13, 2021·Investigational New Drugs·Qiu-Ying DuDong-Sheng Pei
Sep 4, 2021·Immunopharmacology and Immunotoxicology·Guoqiang LinYanming Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Related Papers

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
S L CohnM Haber
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
S B BordowM Haber
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Valerie CombaretM C Favrot
© 2022 Meta ULC. All rights reserved