IGFBP-3. Functional and structural implications in aging and wasting syndromes

Endocrine
M C Gelato, R A Frost

Abstract

Over the last several years, the authors have studied the relationship of insulin-like growth factors (IGFs) and the insulin-like growth factor binding proteins (IGFBPs) in the circulation in a number of clinical settings. Patterns have emerged that seem to be characteristic of various conditions. In aging, there are marked decreases in IGF-I and -II, normal levels of IGFBP-3, and marked increases in IGFBP-1 in serum. Using ligand blotting and an IGFBP-3 proteolysis assay, BP-3 is intact. Based on native gel electrophoresis, IGFBP-1 is in its most highly phosphorylated state in those elders who have high IGFBP-1 levels. This pattern is slightly different in catabolic conditions such as AIDS (wasting in adults; failure to thrive in children), uncontrolled diabetes mellitus, trauma, and severe burns. In these conditions, serum levels of IGF-I and -II are markedly diminished, IGFBP-3 levels are also decreased, and IGFBP-1 levels are markedly increased. In addition, there is increased proteolysis of IGFBP-3 (AIDS failure to thrive, uncontrolled diabetes mellitus) and disruption of the ternary complex with decreased levels of ALS (AIDS wasting and burns). IGFBP-1 is in its most highly phosphorylated state in all catabolic conditions...Continue Reading

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Citations

Sep 14, 2001·The Journal of Experimental Zoology·W N GabrielV A Lance
Aug 7, 2002·International Journal of Cardiology·Marijke BrinkPatrick Delafontaine
Apr 3, 2001·European Journal of Clinical Investigation·D l'Allemand, A Biason-Lauber
Aug 21, 2010·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Wesley David DudgeonGregory Allen Hand
Sep 12, 2000·Neurosurgery·B W ScheithauerW F Young
Feb 8, 2006·Journal of Pediatric Endocrinology & Metabolism : JPEM·Nesibe AndiranSerafettin Kirazli
Jun 1, 2005·Journal of Pediatric Endocrinology & Metabolism : JPEM·Ines Guttmann-Bauman
Jan 10, 2006·Journal of Pediatric Endocrinology & Metabolism : JPEM·Lourdes IbáñezMaria Victoria Marcos
Feb 24, 2007·Journal of Pediatric Endocrinology & Metabolism : JPEM·Elizabeth E LittlejohnRobert Rosenfield
Jul 29, 2008·Journal of Pediatric Endocrinology & Metabolism : JPEM·Lorah D DornSarah L Berga
May 11, 2006·American Journal of Physiology. Endocrinology and Metabolism·Graziano OnderFrancesco Landi
Mar 10, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·V G KaklamaniC Mantzoros

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