PMID: 18425271Apr 22, 2008Paper

IgG and IgG2 antibodies from cattle naturally infected with Anaplasma marginale recognize the recombinant vaccine candidate antigens VirB9, VirB10, and elongation factor-Tu

Memórias do Instituto Oswaldo Cruz
Flábio R AraújoAdivaldo H Fonseca

Abstract

Anaplasma marginale is an important vector-borne rickettsia of ruminants in tropical and subtropical regions of the world. Immunization with purified outer membranes of this organism induces protection against acute anaplasmosis. Previous studies, with proteomic and genomic approach identified 21 proteins within the outer membrane immunogen in addition to previously characterized major surface protein1a-5 (MSP1a-5). Among the newly described proteins were VirB9, VirB10, and elongation factor-Tu (EF-Tu). VirB9, VirB10 are considered part of the type IV secretion system (TFSS), which mediates secretion or cell-to-cell transfer of macromolecules, proteins, or DNA-protein complexes in Gram-negative bacteria. EF-Tu can be located in the bacterial surface, mediating bacterial attachment to host cells, or in the bacterial cytoplasm for protein synthesis. However, the roles of VirB9, VirB10, and TFSS in A. marginale have not been defined. VirB9, VirB10, and EF-Tu have not been explored as vaccine antigens. In this study, we demonstrate that sera of cattle infected with A. marginale, with homologous or heterologous isolates recognize recombinant VirB9, VirB10, and EF-Tu. IgG2 from naturally infected cattle also reacts with these protein...Continue Reading

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Citations

Nov 3, 2010·Transboundary and Emerging Diseases·P Aubry, D W Geale
Feb 24, 2010·Infection and Immunity·Joseph J GillespieBruno W Sobral
Nov 30, 2012·BMC Genomics·Basima Al-KhederyAnthony F Barbet
Jun 21, 2014·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Carlos A N RamosRafael A N Ramos
Jul 17, 2013·Revista brasileira de parasitologia veterinária = Brazilian journal of veterinary parasitology : Órgão Oficial do Colégio Brasileiro de Parasitologia Veterinária·Marcela Ribeiro GaspariniMarilda Carlos Vidotto
Dec 2, 2010·Memórias do Instituto Oswaldo Cruz·Daniel S G JuniorAdivaldo H Fonseca
Jan 1, 2015·Emerging Microbes & Infections·Sebastian E CarrascoX Frank Yang
Dec 20, 2018·BMC Microbiology·Francy L CrosbyAnthony F Barbet
Feb 23, 2018·Frontiers in Microbiology·Marcelina PyclikMonika Brzychczy-Włoch

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