IgG and IgM glycosylation patterns in patients undergoing image-guided tumor ablation

Biochimica Et Biophysica Acta
Lucas D BreenDjuro Josić

Abstract

Image-guided tumor ablation is a technique whereby needle-like applicators are placed directly into solid tumors under guidance typically with computed tomography or ultrasound. Changes in IgG and IgM antibody glycosylation were studied during ablation-induced immune response to cancer, and the use of glycosylation as a biomarker for diagnosis, prognosis and disease treatment was examined. Plasma from 27 tumor patients was collected immediately before, after and for 6 months following ablation. IgG and IgM antibodies were isolated by use high-throughput chromatography, and analyzed by hydrophilic liquid chromatography. Thorough identification of glycan structures in each chromatography peak was performed by nano-liquid chromatography electrospray ionization mass spectrometry. Although antibody glycosylation was found to vary with cancer type, discernable patterns of change based on the successful treatment of tumors by ablation were not identified. One patient with renal clear cell carcinoma and poor disease outcome had unexpectedly high amount of oligomannose IgG glycans during the whole period of monitoring. In contrast, IgM antibodies did not follow the same pattern. These findings suggest that glycosylation patterns are ind...Continue Reading

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Citations

Jun 29, 2017·Molecular Oncology·Radka SaldovaPauline M Rudd
Sep 25, 2018·Electrophoresis·Djuro JosicKresimir Pavelic
Apr 21, 2021·Glycoconjugate Journal·Gerda C M VreekerRob A E M Tollenaar
Nov 22, 2019·Journal of Proteome Research·Olga O ZaytsevaMislav Novokmet

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