IgG anti-laminin-1 autoantibody and recurrent miscarriages

American Journal of Reproductive Immunology : AJRI
J InagakiK Aoki

Abstract

The present study assesses the clinical significance of anti-laminin-1 auto-antibodies (auto-Abs) in recurrent miscarriages. A total of 207 recurrent aborters with a history of two or more consecutive first-trimester miscarriages were tested for the presence of anti-laminin-1 Abs, beta2-glycoprotein I-dependent anticardiolipin Abs, lupus anticoagulants, anti-DNA Abs, and anti-nuclear Abs, before they had conceived again. Recurrent aborters then were followed up during subsequent pregnancies and their outcomes were evaluated relative to their blood test results prior to pregnancy. Fifty-five (31.1%) women out of 177 recurrent aborters were positive for IgG anti-laminin-1 auto-Abs. The levels of IgG anti-laminin-1 auto-Abs in recurrent aborters were significantly higher than those in healthy pregnant women and in healthy non-pregnant women (P = 0.0043 and 0.0073, respectively). The live birth rate of subsequent pregnancies in IgG anti-laminin-1 auto-Abs-positive recurrent aborters was significantly lower than the IgG anti-laminin-1 auto-Abs-negative recurrent aborters (P = 0.0320). There were no specifically significant relationships observed between IgG anti-laminin-1 auto-Abs and other tested auto-Abs. IgG anti-laminin-1 auto-A...Continue Reading

Citations

Feb 23, 2013·Archives of Gynecology and Obstetrics·Arif Kokcu
Oct 21, 2009·Clinical Reviews in Allergy & Immunology·Ricard Cervera, Juan Balasch
May 14, 2010·Human Reproduction Update·K E MayC M Becker
Feb 18, 2016·Autoimmunity Reviews·Silvia D'IppolitoNicoletta Di Simone
Sep 19, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Sezcan MumusogluGulsen Hascelik
Sep 22, 2015·American Journal of Reproductive Immunology : AJRI·Manuela VegliaNicoletta Di Simone
Feb 15, 2012·Autoimmunity Reviews·Vered H EisenbergDavid Soriano
Aug 30, 2005·Annals of the New York Academy of Sciences·Junko InagakiEiji Matsuura
Jul 9, 2003·American Journal of Reproductive Immunology : AJRI·Shelly Tartakover MatalonYehuda Shoenfeld
Jun 24, 2004·American Journal of Reproductive Immunology : AJRI·I MaraiY Shoenfeld
Nov 2, 2006·American Journal of Reproductive Immunology : AJRI·Yehuda ShoenfeldPer Luigi Meroni
Aug 15, 2012·The Journal of Obstetrics and Gynaecology Research·Mayumi Sugiura-OgasawaraTamao Kitaori
Jan 13, 2011·American Journal of Reproductive Immunology : AJRI·Junko InagakiEiji Matsuura
Oct 27, 2004·Seminars in Arthritis and Rheumatism·Yaniv ShererYehuda Shoenfeld
Oct 9, 2012·Autoimmunity·Maria-Carolina PáezJuan-Manuel Anaya
Jan 28, 2016·International Journal of Immunopathology and Pharmacology·Domenico CaccavoRaffaella Depalo
Oct 16, 2004·Lupus·Y Shoenfeld, M Blank
Apr 25, 2007·Autoimmunity·María-Carolina PáezJuan-Manuel Anaya
Mar 8, 2020·International Journal of Molecular Sciences·Costin Vlad AnastasiuLiana-Maria Chicea
Jun 11, 2011·International Journal of Immunopathology and Pharmacology·D CaccavoR Depalo
Mar 17, 2021·Autoimmunity Reviews·Hila GreenbaumVered H Eisenberg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.