IgG anti-melanocyte antibodies purified from patients with active vitiligo induce HLA-DR and intercellular adhesion molecule-1 expression and an increase in interleukin-8 release by melanocytes

The Journal of Investigative Dermatology
Y L LiH S Yu

Abstract

An immunologic hypothesis is currently proposed as a possible pathogenesis of nonsegmental-type vitiligo. IgG antibodies against melanocyte surface antigens exist in the serum of patients with vitiligo vulgaris. IgG anti-melanocyte antibodies were reported to induce melanocyte damage in vitro by a complement-mediated mechanism and antibody-dependent cellular cytotoxicity. Perilesional melanocytes express major histocompatibility complex class II antigens and a higher intercellular adhesion molecule-1 compared with those in normal skin. The purpose of this study was to determine the role of IgG anti-melanocyte antibodies in the inappropriate expression of major histocompatibility complex class II antigens and intercellular adhesion molecule-1 on melanocytes. IgG anti-melanocyte antibody samples were purified from the individual serum of patients with active vitiligo. After incubation of IgG anti-melanocyte antibodies with cultured melanocytes, the results revealed: (i) IgG anti-melanocyte antibody stimulated HLA-DR expression on melanocytes; (ii) intercellular adhesion molecule-1 expression on melanocytes was significantly induced by IgG anti-melanocyte antibodies; and (iii) IgG anti-melanocyte antibodies induced an increase in ...Continue Reading

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Citations

Feb 22, 2011·Autoimmunity Reviews·Manuel Sandoval-CruzAlejandro Ruiz-Argüelles
Jun 15, 2012·The Journal of Investigative Dermatology·Siavash ToosiPrashiela Manga
Jun 11, 2005·Experimental Dermatology·Cheng-Che E LanHsin-Su Yu
Nov 5, 2005·Journal of the European Academy of Dermatology and Venereology : JEADV·S FarrokhiN Rezaei
Jul 16, 2003·Pigment Cell Research·Yvon GauthierAlain Taïeb
Jul 31, 2007·Journal of the European Academy of Dermatology and Venereology : JEADV·N RezaeiE H Kemp
May 7, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·C-S WuH-S Yu
Jan 1, 2013·Qatar Medical Journal·Mohamed Allam, Hassan Riad
Nov 22, 2018·Expert Review of Clinical Immunology·Mala SinghRasheedunnisa Begum
Oct 7, 2005·Autoimmunity·Selwyn ChowAnimesh A Sinha
Aug 31, 2011·Archives of Dermatological Research·Shujie ZhangLeihong Xiang
Mar 21, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·N KaracaA Berdeli
Mar 8, 2003·Pigment Cell Research·Katia OngenaeJean-Marie Naeyaert
Oct 20, 2004·The Journal of Dermatology·Chih-Hung Lee, Hsin-Su Yu

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