IgG-antiphospholipid antibodies in follicular fluid of IVF-ET patients are related to low fertilization rate of their oocytes

American Journal of Reproductive Immunology : AJRI
Hidehiko MatsubayashiJohn A McIntyre

Abstract

Patients undergoing in vitro fertilization and embryo transfer (IVF-ET) failures show an increased incidence of antiphospholipid antibodies (aPL) in their blood. The physiological manifestations of aPL in this patient group are nonetheless controversial. Pathological effects of aPL on embryos in vitro have been documented. We questioned whether aPL if found in follicular fluids (FFs) could result in embryonic damage. Blood from 44 patients with three or more IVF-ET failures were tested by enzyme-linked immunosorbent assays (ELISA) for the presence of immunoglobulin (Ig)G, IgM and IgA aPL. Both the 29 aPL-positive and 15 aPL-negative patients gave permission for FF collection during their next IVF-ET attempt for additional aPL determinations. Patients with no aPL in their blood, had no aPL in their FFs. Patients with IgG and/or IgM aPL in their blood had IgG but not IgM in their respective FFs. The presence of IgG aPL in FFs and increased infertility length were significantly related to lower fertilization rates, independently. Follicular fluid IgG aPL appears as a risk factor in association with successful IVF-ET outcomes.

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Citations

Feb 27, 2009·Journal of Reproductive Immunology·K L Buckingham, L W Chamley
Jul 19, 2011·American Journal of Reproductive Immunology : AJRI·Yi-Ping ZhongJing Li
Oct 18, 2014·Journal of Perinatal Medicine·Katarina JeremicJelena Jeremic
Aug 15, 2008·Human Reproduction Update·Scott M Nelson, Ian A Greer
Dec 13, 2019·Lupus·G El HasbaniI Uthman
Jul 18, 2009·Reproductive Medicine and Biology·Hidehiko Matsubayashi
Feb 23, 2019·International Journal of Molecular Sciences·Mara SimopoulouMichael Koutsilieris
May 22, 2018·Obstetrics & Gynecology Science·Yeon Hee HongSeok Hyun Kim
Dec 4, 2020·Journal of Reproductive Immunology·Soodeh MahdianMaryam Shahhoseini
Sep 21, 2020·Journal of Gynecology Obstetrics and Human Reproduction·Xiaofang TanJie Wu

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