IgG immune complex-binding in macrophages from arthritis-susceptible and arthritis-resistant mice following collagen type II immunization

Scandinavian Journal of Immunology
L ThorvaldsonS Kleinau

Abstract

Occupancy of Fc gamma receptors (FcgammaR) by immune complexes (IC) induces secretion of various inflammatory mediators and cytokines. Therefore, knowledge of the FcR function is fundamental for understanding inflammatory processes. Here, we report an alteration in the FcR function in collagen-induced arthritis (CIA). The FcgammaR-binding activity of peritoneal macrophages from arthritis-susceptible DBA/1 mice following collagen type II (CII)/CFA immunization was assessed by Fc rosetting of SRBC opsonized with different IgG subclasses. A progressive reduction of IgG1 IC-binding was observed after immunization, and by the time of arthritis onset, the IgG1 IC-binding was abolished. Binding of IgG2a or IgG2b IC, however, was not affected. The blocked IgG1 IC-binding was reversed by a prior mild acid wash of the CIA macrophages, indicating receptor occupancy as the cause of the blocked binding. The impaired IgG1 IC-binding was associated with arthritis development, as macrophages from CII/CFA-immunized, arthritis-resistant SWR mice or DBA/1 mice, immunized with CFA alone, did not show this effect. Normal DBA/1 macrophages, blocked with a monoclonal antibody to FcgammaRIIB/FcgammaRIII, and macrophages from FcgammaRIII-deficient mice...Continue Reading

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Apr 21, 2006·Scandinavian Journal of Immunology·M AndrénS Kleinau

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Citations

Oct 6, 2009·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Tomohiro ArikawaMitsuomi Hirashima
Sep 10, 2014·Immunology Letters·Sofia E MagnussonSandra Kleinau
Jan 18, 2011·Molecular Immunology·David R GibbDaniel H Conrad
Sep 8, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mark H WeninkTimothy R D J Radstake
Jul 7, 2017·Frontiers in Microbiology·Maya YamashitaTadaaki Miyazaki

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