IgG keeps virulent Salmonella from evading dendritic cell uptake.

Immunology
Sebastián A RiquelmeAlexis M Kalergis

Abstract

Dendritic cells (DCs) are phagocytic professional antigen-presenting cells that can prime naive T cells and initiate anti-bacterial immunity. However, several pathogenic bacteria have developed virulence mechanisms to impair DC function. For instance, Salmonella enterica serovar Typhimurium can prevent DCs from activating antigen-specific T cells. In addition, it has been described that the Salmonella Pathogenicity Island 1 (SPI-1), which promotes phagocytosis of bacteria in non-phagocytic cells, can suppress this process in DCs in a phosphatidylinositol 3-kinase (PI3K) -dependent manner. Both mechanisms allow Salmonella to evade host adaptive immunity. Recent studies have shown that IgG-opsonization of Salmonella can restore the capacity of DCs to present antigenic peptide-MHC complexes and prime T cells. Interestingly, T-cell activation requires Fcγ receptor III (FcγRIII) expression over the DC surface, suggesting that this receptor could counteract both antigen presentation and phagocytosis evasion by bacteria. We show that, despite IgG-coated Salmonella retaining its capacity to secrete anti-capture proteins, DCs are efficiently capable of engulfing a large number of IgG-coated bacteria. These results suggest that DCs emplo...Continue Reading

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Citations

Oct 16, 2015·European Journal of Immunology·Sebastián A RiquelmeAlexis M Kalergis
May 23, 2013·Immunology·Juan P Mackern-ObertiAlexis M Kalergis
Feb 6, 2014·Veterinary Microbiology·Chetan V JawaleJohn Hwa Lee
Dec 12, 2012·Virulence·A Leoni Swart, Michael Hensel
Jun 1, 2014·Comparative Immunology, Microbiology and Infectious Diseases·Chetan V Jawale, John Hwa Lee
Sep 23, 2014·Veterinary Immunology and Immunopathology·Chetan V Jawale, John Hwa Lee

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