IgG monitoring to identify the risk for development of infection in heart transplant recipients

Transplant Infectious Disease : an Official Journal of the Transplantation Society
E SarmientoJ Carbone

Abstract

Infectious complication represents a significant source of morbidity and mortality in heart transplant recipients. To assess humoral immunity markers that can predict the development of infection, 38 consecutive recipients of heart transplants performed at a single center were prospectively studied. Induction therapy included daclizumab. Immunoglobulin (IgG, IgA, IgM) and complement factors (C3, C4, and factor B) were performed by nephelometry in peripheral blood samples obtained before transplantation, and 7 days and 1 month after transplantation. During a mean follow-up of 16.9 months, 13 patients had at least one episode of infection (34.2%). Eight of these were cytomegalovirus (CMV) infections treated with intravenous ganciclovir, 2 were bacterial pneumonia, 1 patient had bacterial septicemia, 1 patient had urinary tract infection, and 1 patient had pulmonary nocardiosis. No significant association was found between infection and age, sex, immunosuppression, CMV serostatus of donor and recipient, or treated rejection episodes. Pre-transplant IgG (below median value=1140 mg/dL; relative risk [RR] 3.69; 95% confidence interval [CI] 1.01-13.54; P=0.04) and post-transplant IgG levels at day 7 (below median value=679 mg/dL; RR 1...Continue Reading

References

Aug 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P MuñozE Bouza
Mar 1, 1996·Current Opinion in Cardiology·S J Thaler, R H Rubin
Aug 1, 1997·The Journal of Infectious Diseases·O B SpillerF Tufaro
Apr 11, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·M H YamaniR C Starling
Jun 29, 2001·Transplant Infectious Disease : an Official Journal of the Transplantation Society·R CoralesR K Avery
Aug 7, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J G MontoyaJ S Remington
Apr 3, 2002·Transplant Infectious Disease : an Official Journal of the Transplantation Society·M H YamaniR C Starling
Mar 17, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Patricia MuñozManuel Desco
Aug 3, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·David O TaylorMarshall I Hertz

❮ Previous
Next ❯

Citations

Apr 16, 2009·Current Infectious Disease Reports·Javier CarboneElizabeth Sarmiento
Jul 31, 2013·Transplantation·Camille N KottonUNKNOWN Transplantation Society International CMV Consensus Group
Jan 10, 2014·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Akihiro OhsumiHiroshi Date
Dec 17, 2014·Clinical & Translational Immunology·Mario Fernández-RuizAtul Humar
May 11, 2012·Enfermedades infecciosas y microbiología clínica·Patricia Muñoz, María G Crespo Leiro
Sep 3, 2014·Transplant Infectious Disease : an Official Journal of the Transplantation Society·E SarmientoJ Carbone
Oct 23, 2008·International Immunopharmacology·Elizabeth SarmientoJavier Carbone
Jul 16, 2008·Seminars in Arthritis and Rheumatism·Daniel E Furst
Sep 12, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Patricia MuñozEmilio Bouza
Oct 1, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Mario Fernández-RuizJose María Aguado
Jul 29, 2008·Transplant Infectious Disease : an Official Journal of the Transplantation Society·J CarboneE Fernandez-Cruz
Aug 8, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D F FlorescuU Sandkovsky
Jun 12, 2013·Transplant International : Official Journal of the European Society for Organ Transplantation·Nallibe LanioJavier Carbone
Jul 25, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M Fernández-RuizJ M Aguado
Sep 28, 2012·Transplant Infectious Disease : an Official Journal of the Transplantation Society·E SarmientoJ Carbone
Jan 20, 2015·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Jackrapong BruminhentRaymund R Razonable
Oct 26, 2016·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Elizabeth SarmientoJavier Carbone
Apr 21, 2011·Expert Review of Anti-infective Therapy·Javier CarboneElizabeth Sarmiento
Oct 7, 2019·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Margaret NewmanDavid Pitrak
Sep 11, 2017·Analytical and Bioanalytical Chemistry·Inês I RamosMarcela A Segundo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.