PMID: 2497181Jun 1, 1989Paper

IgG subclass responses to a transmembrane protein (gp41) peptide in HIV infection

The Journal of Immunology : Official Journal of the American Association of Immunologists
F ChiodiB Wahren

Abstract

The IgG subclass distribution to the E34/E32 peptides, derived from the HIV-1 glycoprotein 41 transmembrane protein, was analyzed in ELISA. Sera from individuals at different stages of the disease were assayed. A restricted subclass response of mainly IgG1 and IgG2 was found. The subclass response was of a different type than the one observed to HIV whole Ag and to a synthetic peptide from the C'-terminal part of the HIV-1 p24 core protein. An increased subclass restriction was observed in progressed stages of the disease.

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