IgG subclass responses to pigeon intestinal mucin are related to development of pigeon fanciers' lung

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
C I BaldwinJ E Calvert

Abstract

Pigeon fanciers' lung (PFL) is a form of extrinsic allergic alveolitis. Affected individuals produce antibodies to various pigeon antigens, and the resulting immune complexes are thought to initiate the disease. However, high antibody titres also occur in some asymptomatic individuals. Previously attention has focused on protein antigens, but we have recently identified pigeon intestinal mucin as a novel antigen in PFL. To determine the relationship between IgG subclass antibodies to pigeon intestinal mucin and the development of pigeon fanciers' lung. Sera were collected from 250 pigeon fanciers, who also completed a clinical questionnaire. Sera were screened for precipitating antibodies to pigeon serum and droppings. Individuals with symptoms and precipitating antibodies were considered to have classical PFL. Serum IgG and IgG subclass antibodies to pigeon intestinal mucin and pigeon serum proteins were investigated by quantitative enzyme-linked immunosorbent assay (ELISA). Very high titres of IgG antibodies against pigeon mucin were found in all precipitin-positive individuals. A strong positive correlation was seen between titres of antibodies to mucin and to serum proteins, but this was not due to crossreactivity. No signi...Continue Reading

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Citations

Jul 9, 2005·Carbohydrate Research·C I BaldwinE F Hounsell
Jul 9, 2002·Allergy·P J F M Merkus, A W van Toorenenbergen
Jul 9, 2002·Allergy·M Rosal-SanchezM Blanca
Mar 18, 2008·Medicine·Ferran MorellXavier Muñoz
Aug 25, 2005·Paediatric Drugs·Purnima Venkatesh, Laurianne Wild
Aug 12, 1999·Clinical and Experimental Immunology·C I BaldwinJ E Calvert
Aug 26, 1998·Clinical and Experimental Immunology·C I BaldwinJ E Calvert
Mar 3, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J E CalvertS J Bourke
Jan 8, 2013·Molecular Immunology·Zohreh NademiChristopher Baldwin
Feb 13, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D E Aguilar LeónE Martínez-Cordero
May 28, 2016·The European Respiratory Journal·Christine CramerHenrik Albert Kolstad

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