IgG subclass-restricted immune responses to allergens

Springer Seminars in Immunopathology
A H Lucas

Abstract

The IgG responses to a variety of allergens are predominated by IgG1 and IgG4 antibodies. With several allergens, the IgG1 response appears to precede the IgG4 response and this switch may be driven by repeated allergen exposure. It remains to be determined whether there is any causal relationship between subclass restriction and the regulation of specific IgE. The question of whether IgG4 antibodies are protective or pathological is still unresolved. Human models are needed to further analyze the interrelationships between T cells, cytokines and B cell isotype expression. The antibody response to allergens appears to be an ideal experimental system for studying antigen-specific isotype regulation in humans. The subclass patterns are remarkably reproducible between individuals, and allergic and normal human subjects, who have been immunized naturally or therapeutically, are readily available as a source of cells. Isolation of allergen-specific T cells that putatively regulate subclass expression would seem to be a worthwhile endeavor. Understanding the molecular and cellular events that initiate and control isotype expression will play an important role in the rational design of immunogens and therapeutics, aimed at optimizing ...Continue Reading

Citations

Jan 8, 1999·Veterinary Immunology and Immunopathology·T M Lian, R E Halliwell
Jan 11, 2001·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Y K KimK U Min
Jul 3, 1998·The Journal of Clinical Investigation·C A AkdisK Blaser
Mar 10, 1998·Research in Veterinary Science·A P FosterD J DeBoer
Sep 20, 2005·Journal of the Neurological Sciences·Alberto Juan Dorta-ContrerasBárbara Padilla Docal
Aug 28, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S HemmannR Crameri
Sep 9, 1999·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·M C Jenmalm, B Björkstén
Mar 30, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C A Akdis, K Blaser

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.

© 2021 Meta ULC. All rights reserved