PMID: 2422139Dec 1, 1985Paper

IgG vs IgE: mediators of antigen-induced guinea pig lung parenchymal contraction

Immunopharmacology
J F Regal

Abstract

The present studies were conducted to determine whether different mediators are responsible for antigen-induced contraction of guinea pig lung parenchymal strips sensitized with either IgG or IgE. Passive sensitization was employed using IgG- or IgE-type antibody to ovalbumin which had been separated using Protein A-Sepharose as previously described (Regal, 1984a). Such a system ensures the presence of only one type of cytophilic antibody to mediate antigen-induced contraction of the isolated lung parenchymal strip. Pyrilamine, an H1 antagonist, caused a very slight delay in the onset of the antigen-induced contractions in both IgG- and IgE-sensitized strips, suggesting a very minor role for endogenous histamine in both systems. A combination of the leukotriene antagonist, FPL 55712, and pyrilamine caused a significant reduction in the antigen-induced contraction in IgG- but not IgE-sensitized lung parenchymal strips. Histamine release was detected on antigen challenge of both IgG- and IgE-sensitized lung. Using bioassay techniques, leukotriene release was primarily detected from IgG-sensitized lung and only minimally from IgE-sensitized lung. Thus, our studies have demonstrated a differential antagonism of IgG- and IgE-mediate...Continue Reading

References

Jun 1, 1975·Journal of Immunological Methods·R P Siraganian
Feb 1, 1966·Proceedings of the Society for Experimental Biology and Medicine·R A Reisfeld, N E Hyslop
Jan 1, 1982·International Archives of Allergy and Applied Immunology·I KatayamaT Doi

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