PMID: 3744580Jan 1, 1986Paper

IgG1 antibodies to house dust mite (Dermatophagoides farinae) and late asthmatic response

International Archives of Allergy and Applied Immunology
K ItoK Ohta

Abstract

Thirteen asthmatic patients sensitive to mite were challenged by inhalation of an extract of mites (Dermatophagoides farinae). Seven showed dual bronchial reactions and 5 showed isolated immediate responses. No patient showed an isolated late reaction. Six of seven patients with dual reaction had higher IgG1 antibodies than the 5 patients with isolated immediate reaction when examined before the challenge. A similar result was obtained in terms of levels of immune complex. IgE, IgG4 and total IgG antibodies were not predictive for late reaction. These results suggest that there is a close correlation of the presence of high IgG1 antibodies with a propensity to develop late asthmatic responses. The meaning of this observation is discussed.

Citations

Jul 1, 1997·American Journal of Respiratory and Critical Care Medicine·H TakanoM Sagai
Jun 1, 1995·The Journal of Clinical Investigation·M KanekoH Kita
Jan 1, 1994·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B MosimannA Pécoud
Dec 17, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Tina StevensM Ian Gilmour
May 1, 1991·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T Nakagawa

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