IgG1-mediated acute pulmonary hypersensitivity response in the guinea pig. Involvement of specific lipid mediators

The American Review of Respiratory Disease
J W WatsonH J Showell

Abstract

We determined the pulmonary obstructive response to aerosolized antigen challenge, and its sensitivity to antagonists of specific lipid mediators, in IgG, passively sensitized (IgG1-PS) guinea pigs. Antiovalbumin (OA)-IgG1 was isolated by affinity chromatography from serum derived from actively immunized Hartley guinea pigs. Propranolol and pyrilamine pretreated, IgG1-PS guinea pigs were challenged with aerosolized antigen and pulmonary obstruction was quantified by measurements of excised lung gas volume (ELGV). ELGV increased between 150 and 1,035% in a dose-proportional fashion with increasing antigen exposure (0.001 to 0.1% nebulizer concentration). The leukotriene antagonists ICI-204,219 and SKF-104,353 exhibited dose-proportional inhibitions in antigen-induced elevations in ELGV, inhibiting up to 65 and 87% at the maximal concentrations examined. Similarly, the platelet-activating factor (PAF) antagonists WEB-2086 and L-659,989 inhibited antigen-induced elevations in ELGV, inhibiting up to 94 and 59% at the maximal concentrations examined. In contrast, the cyclooxygenase (CO) inhibitor piroxicam significantly enhanced (p less than 0.05) the OA-induced elevations in ELGV. Aerosolized PAF challenge produced dose-proportiona...Continue Reading

References

Apr 1, 1987·Prostaglandins·P W StengelS A Silbaugh
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Feb 1, 1986·Respiration Physiology·P W Stengel, S A Silbaugh
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Citations

Mar 3, 1994·European Journal of Pharmacology·P W StengelS A Silbaugh
Oct 1, 1995·Respiration Physiology·C A YiamouyiannisS A Silbaugh
Jan 1, 1995·Neuropeptides·C A YiamouyiannisS A Silbaugh
May 24, 2005·Respiratory Physiology & Neurobiology·Anne-Helene JanssonXiangdong Wang
Jan 5, 1999·Bioorganic & Medicinal Chemistry Letters·R J ChambersJ W Watson
Jan 5, 1999·Bioorganic & Medicinal Chemistry Letters·M F BrownJ W Watson
Feb 6, 1999·Bioorganic & Medicinal Chemistry Letters·R J ChambersJ W Watson
Sep 1, 1993·Journal of Toxicology and Environmental Health·D Griffiths-JohnsonM H Karol

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