PMID: 6166572Jan 1, 1981Paper

IgG4 and passive sensitization of basophil leukocytes

International Archives of Allergy and Applied Immunology
A W van Toorenenbergen, R C Aalberse

Abstract

In contrast to IgE, myeloma IgG4 did not block passive sensitization of basophil leukocytes by IgE antibody. Atopic sera, selected for a high level of mite-specific IgG4, lost their sensitizing activity after they had been heated at 56 degrees C. After incubation of leukocytes with myeloma IgG4 or with sera with high levels of specific IgG4, the cells did not become responsive towards anti-IgG4 antiserum. After incubation of leukocytes with fluorescein-labelled myeloma IgE, these cells released histamine with antifluorescein antiserum. In contrast, after incubation with fluorescein-labelled myeloma IgG4, a subsequent incubation with antifluorescein antiserum did not result in histamine release. Therefore, we cannot confirm the hypothesis of Vijay and Perelmutter that IgG4 can sensitize basophil leukocytes in vitro.

Citations

Mar 1, 1984·The Journal of Allergy and Clinical Immunology·M BallowP Rapacz
Feb 1, 1995·The Journal of Clinical Investigation·M DaëronW H Fridman
Feb 19, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R C AalberseT Rispens
Jan 1, 1990·Critical Reviews in Oncology/hematology·P Valent, P Bettelheim
Mar 30, 1984·The American Journal of Medicine·D C Heiner
Dec 3, 2014·Immunology Letters·Rob C Aalberse, Edward F Knol
May 10, 2006·Advances in Immunology·Marc Daëron, Renaud Lesourne
Jul 25, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J SchuurmanR C Aalberse
Jul 1, 1987·The Annals of Otology, Rhinology, and Laryngology·Y OhashiT Miyamoto
Nov 1, 1992·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L JimenoJ Moscoso Del Prado
Nov 1, 1993·Allergy·R C AalberseS O Stapel
Apr 25, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M TarziM Larché
Jan 1, 1997·International Reviews of Immunology·I A Heijnen, J G van de Winkel
Jan 1, 1983·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·L E MansfieldP H Schur
Jul 1, 1990·Journal of Clinical Microbiology·J A ShortF L Andersen

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