IgG4-related Disease and the Liver

Gastroenterology Clinics of North America
Jonathan H Chen, Vikram Deshpande

Abstract

Pathologists are likely to encounter IgG4-related disease in several organ systems. This article focuses on helping pathologists diagnose IgG4-related disease in the hepatobiliary system. Missing the diagnosis can result in unnecessary organ damage and/or unnecessary surgical and cancer therapy. In the liver, tumefactive lesion(s) involving the bile ducts with storiform fibrosis and an IgG4-enriched lymphoplasmacytic infiltrate are highly concerning for IgG4-related disease. The recent identification of oligoclonal populations of T cells and B cells in IgG4-related disease may lead to molecular tests, new therapeutics, and a greater mechanistic understanding of the disease.

Citations

Feb 22, 2018·International Journal of Surgical Pathology·Jonathan H Chen, Vikram Deshpande
Sep 4, 2018·Scandinavian Journal of Gastroenterology·Min Liu, Mingju Hao
Feb 11, 2020·Insights Into Imaging·Ali Devrim KaraosmanogluPeter F Hahn
Jun 21, 2018·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Jacob R BledsoeVikram Deshpande
Oct 12, 2018·Case Reports in Pathology·Malene Theilmann ThinesenSönke Detlefsen
Apr 19, 2020·International Immunopharmacology·Abdullah Al MamunJian Xiao
Aug 3, 2021·The American Journal of Surgical Pathology·Kshitij S AroraVikram Deshpande
Nov 16, 2021·Clinical Advances in Periodontics·Ivonne A HernándezLiran Levin
May 18, 2021·The American Journal of Surgical Pathology·M Lisa Zhang, Vikram Deshpande

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