IgG4-related inflammatory pseudotumor of the renal pelvis involving renal parenchyma, mimicking malignancy

Diagnostic Pathology
Ho Gyun Park, Kyoung Min Kim

Abstract

IgG4-related disease is a recently recognized systemic disease characterized by storiform fibrosis with infiltration of IgG4-positive plasma cells. In rare incidences, IgG4-related renal disease can present as a solitary mass lesion at renal pelvis and can pose a diagnostic challenge since these lesions mimic malignancy. Herein, we present a rare case of IgG4-related disease presenting as inflammatory pseudotumor lesion, involving the renal pelvis and also neighboring renal parenchyma. A 75-year-old man with no history of IgG4-related disease underwent computed tomography (CT) scan for evaluation of prostatic cancer. The CT scan incidentally revealed a mass lesion located at the right renal pelvis. Radiologic findings were highly suggestive of malignancy. Therefore, the patient underwent right nephroureterectomy. Microscopically, the mass lesion showed storiform fibrosis with diffuse and intense inflammatory cell infiltration. Infiltrating cells were mainly histiocytes and plasma cells. Tubulointerstitium adjacent to the lesion also showed fibrosis with abundant plasmacytic infiltration. Immunohistochemical staining revealed the presence of IgG4-positive plasma cells in both the mass lesion and tubulointerstitium (mean of 94/HP...Continue Reading

References

Mar 10, 2001·The New England Journal of Medicine·H HamanoK Kiyosawa
Nov 14, 2003·Journal of Gastroenterology·Terumi KamisawaHitoshi Nakajima
Jul 9, 2008·World Journal of Gastroenterology : WJG·Terumi Kamisawa, Atsutake Okamoto
Nov 26, 2010·The American Journal of Surgical Pathology·Yoh Zen, Yasuni Nakanuma
Aug 27, 2011·Clinical and Experimental Nephrology·Shinichi NishiTakako Saeki
Feb 10, 2012·The New England Journal of Medicine·John H StoneVikram Deshpande
Sep 12, 2012·Urologia Internationalis·Tateki YoshinoNoriaki Sanda
Oct 9, 2012·Best Practice & Research. Clinical Rheumatology·Monica Guma, Gary S Firestein
Oct 25, 2012·Case Reports in Urology·Ahmad AlkhasawnehRobert W Allan
Oct 11, 2013·Kidney International·Takako Saeki, Mitsuhiro Kawano
Jun 16, 2014·Seminars in Ultrasound, CT, and MR·Hassan Al ZahraniHyun-Jung Jang
Dec 30, 2014·World Journal of Surgical Oncology·Yiwei WangJianming Guo

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Citations

May 7, 2020·AJR. American Journal of Roentgenology·Minobu KamoJin Yamamura
Mar 17, 2017·F1000Research·Anna R Wolfson, Daniel L Hamilos
May 21, 2019·Clinical Nuclear Medicine·Yuanyuan JiangWuying Cheng
Mar 18, 2020·Abdominal Radiology·Jian LingYan Guo
Oct 23, 2020·Clinical Case Reports·Che-Wei ChangJhen-Hao Jhan
Mar 7, 2021·Clinics and Practice·Claudia ManiniJosé I López

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Methods Mentioned

BETA
biopsy
dissection

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