IgG4-related kidney disease--A review

Pathology, Research and Practice
Dinesh PradhanSambit Kumar Mohanty

Abstract

IgG4-related disease (IgG4-RD) is a recently recognized systemic autoimmune disorder characterized by high levels of serum IgG4 and dense infiltration of IgG4-positive plasma cells in multiple organs. The condition was first described as a disease of the pancreas, and has since been recognized in various organ systems including the kidneys. IgG4 related kidney disease (IgG4-RKD) signifies any form of renal involvement by IgG4-RD. The most common renal involvement by IgG4-RD is tubulointerstitial nephritis. Glomerular disease, in particular membranous glomerulonephritis, may also be seen. Other co-existent glomerular diseases such as IgA nephropathy, membranoproliferative glomerulonephritis, and mesangioproliferative immune complex glomerulonephritis may be identified. IgG4-related plasma cell arteritis has also been noted in the kidney. As with IgG4-RD in general, IgG4 related kidney disease (IgG4-RKD) usually occurs in middle-aged to elderly men. Common findings in IgG4-RKD are plasma cell-rich interstitial inflammatory infiltrate either in a focal or diffuse pattern with increased IgG4+ plasma cells, expansile swirling interstitial fibrosis, high levels of serum IgG and IgG4, hypocomplementemia, high serum IgE levels and/or p...Continue Reading

References

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Citations

May 4, 2016·Clinical Rheumatology·David Herrera van OostdamCarlos Abud Mendoza
May 17, 2018·Oncotarget·Giacomo QuattrocchioDario Roccatello
Mar 15, 2016·Journal of Nephrology·Giacomo Quattrocchio, Dario Roccatello
Jan 24, 2018·World Journal of Nephrology·Maurizio Salvadori, Aris Tsalouchos
Mar 9, 2021·Clinical and Experimental Medicine·Leonardo SpatolaEnrico Eugenio Minetti

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