IGIV: contents, properties, and methods of industrial production--evolving closer to a more physiologic product

International Immunopharmacology
Turf D Martin

Abstract

Is the process the product? Immune globulin intravenous (IGIV) is not manufactured, but is purified (fractionated) from human plasma. Machines can only damage what Mother Nature makes; they cannot improve it. Therefore, fractionators of biologic molecules must strive to ensure what is taken from a human body is exactly the same when it is returned to the human body for optimal tolerability and safety. The processes of purification have the potential to adversely affect the product. Four primary purification processes exist for commercial IGIV. The Cohn-Oncley process is 1940s technology, which has been modified through the decades, but the basic process remains unchanged. The Kistler-Nitschmann process was developed in the 1950s by the Central Laboratory of the Swiss Red Cross (ZLB, today known as ZLB-Behring, a subsidiary of CSL Limited). Various attempts have been made to utilize chromatography as the sole separation technology without much success. Most recently, Bayer HealthCare (Talecris Biotherapeutics acquired the contributed assets of the worldwide plasma business of Bayer Biological Products and became operational April 1, 2005; all plasma-based products, including Gamunex, Prolastin, the hyperimmune line (Fraction II)...Continue Reading

References

Jan 1, 1975·Vox Sanguinis·W Stephan
Jan 1, 1991·Vox Sanguinis·J L Lundblad, R L Seng
Feb 25, 1999·São Paulo Medical Journal = Revista Paulista De Medicina·B T Costa-CarvalhoC K Naspitz
Aug 11, 2000·American Journal of Hematology·A S WolbergM Hoffman

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Citations

Jan 29, 2008·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Shoban Davé, John Hagan
Jun 19, 2009·Journal of the American Chemical Society·Başar BilgiçerGeorge M Whitesides
Aug 27, 2010·Journal of Pharmaceutical Sciences·Satish Kumar Singh
May 9, 2012·Immunology and Allergy Clinics of North America·Shien-Ning Chee, Dédée F Murrell
Sep 20, 2011·Dermatologic Clinics·Shien-Ning Chee, Dédée F Murrell
Mar 24, 2016·Biomolecules·Ana Filipa Barahona Afonso, Cristina Maria Pires João
Sep 27, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Fabiola CecchiSimonetta Vannucchi
Jan 30, 2015·Frontiers in Immunology·Andrea MatucciAlessandra Vultaggio
Jun 2, 2018·Clinical and Experimental Dermatology·F GalimbertiA P Fernandez
Nov 1, 2007·Dermatologic Therapy·Anthony P Fernandez, Francisco A Kerdel
Jul 14, 2010·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Patrick Chérin, Jean Cabane
Aug 4, 2018·Frontiers in Immunology·A Razzaque Ahmed, Srinivas Kaveri
Mar 2, 2021·Bulletin of the National Research Centre·Heba K Nabih

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