PMID: 11903383Mar 21, 2002Paper

IgM antibodies identified by a DTT-ameliorated positive crossmatch do not influence renal graft outcome but the strength of the IgM lymphocytotoxicity is associated with DR phenotype

Clinical Transplantation
C F BryanA M Luger

Abstract

A positive crossmatch that is rendered negative by treating the serum with the IgM-reducing agent dithiothreitol (DTT) is generally reported not to influence short-term renal graft outcome. Its effect on long-term (> or = 3 years) cadaveric and live-donor transplant function, however, is less clear. We evaluated the effect of IgM antibodies in a DTT-ameliorated positive crossmatch (DTT-APXM) on long-term renal graft outcome in 1,290 consecutive cadaveric renal transplants (8-year survival) and 384 live-donor renal transplants (7-year survival) from patients transplanted between 1990 and 1999. The data show that 1- and 8-year graft survival for cadaveric renal transplants in patients with IgM antibodies (n=72) (DWFG censored = 91% and 65%; DWFG not censored = 90% and 60%) was not significantly different from the group without IgM antibodies (n = 1,218) (DWFG censored = 92% and 71%; DWFG not censored = 87% and 55%) (log-rank = 0.25 for DWFG censored, log-rank = 0.92 for DWFG not censored). The one- and seven-year graft survival for live-donor renal transplants in patients with IgM antibodies seen in a DTT-APXM (n = 22) (DWFG censored = 95% and 83%; DWFG not censored = 95% and 66%) was not significantly different from the group wi...Continue Reading

References

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Citations

May 3, 2011·Journal of Immunological Methods·Hooi Sian Eng, Mary S Leffell
Mar 21, 2009·Transplantation Reviews·Kathryn Tinckam
Mar 18, 2008·Free Radical Biology & Medicine·Marina E SolovievaVladimir S Akatov
Nov 25, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Howard M GebelPeter Nickerson
Sep 11, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H S EngG R Russ
May 29, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S MittalS V Fuggle
Jul 6, 2014·Transplant International : Official Journal of the European Society for Organ Transplantation·Andrew BentallMark D Stegall
May 20, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Edward J Filippone, John L Farber
May 4, 2005·Lancet·Gerhard Opelz, UNKNOWN Collaborative Transplant Study
Oct 3, 2012·Nature Reviews. Nephrology·Mark D StegallLynn D Cornell
Mar 26, 2015·Journal of the American Society of Nephrology : JASN·Ana Konvalinka, Kathryn Tinckam
May 1, 2008·Expert Review of Clinical Immunology·Cathi L Murphey, Thomas G Forsthuber
Feb 4, 2014·Transplantation·Matthew J EverlyPaul I Terasaki
Nov 21, 2014·Violence Against Women·Alice Cepeda, Kathryn M Nowotny
Mar 10, 2016·The International Journal of Artificial Organs·Alyssa A RileyDeepa H Chand
Sep 20, 2017·Clinical Transplantation·Volker DanielGerhard Opelz

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