PMID: 6318694Jan 1, 1983Paper

IgM detection by ELISA in the diagnosis of cytomegalovirus infections in homosexual and heterosexual immunosuppressed patients

Archives of Virology
E Buimovici-KleinZ Cooper


A new commercially developed cytomegalovirus (CMV)-IgM ELISA was found to be sensitive and specific when compared with sucrose gradient fractionation of Ig classes in CMV antibody-positive and negative sera. The presence of CMV IgM in patients' sera correlated with positive virus isolation from circulating mononuclear blood cells and urine. Serial examinations of patients with primary or recent CMV infection revealed a typical sequence of IgM and IgG development. The frequency of CMV isolation declined as the concentration of IgM decreased and the IgG levels increased. Since the isolation of CMV from clinical specimens is a cumbersome procedure, we suggest that the IgM ELISA could provide rapid and valuable information on the presence of an active or reactivated CMV infection.


Jun 1, 1977·Journal of Clinical Microbiology·H SchmitzA Vogt
Oct 1, 1979·The Journal of Infectious Diseases·A C HekkerR C Meijers
Aug 1, 1979·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A J O'Beirne, H R Cooper
Jan 1, 1979·Journal of Clinical Pathology·F KleinJ M Singer
May 1, 1968·The Journal of Pediatrics·M P HancockJ L Sever
Sep 12, 1968·The New England Journal of Medicine·J B HanshawC J White
Jun 12, 1969·The New England Journal of Medicine·K M Foster, I Jack
May 20, 1971·The New England Journal of Medicine·A M PrinceD S David
Oct 12, 1972·The New England Journal of Medicine·D J Lang, J F Kummer
Jul 5, 1973·The New England Journal of Medicine·D W ReynoldsC A Alford
Jun 1, 1982·Annals of Internal Medicine·L MorrisS Karpatkin
Feb 1, 1981·The Journal of Infectious Diseases·W L DrewB Ketterer
Jun 1, 1982·Annals of Internal Medicine·A E Friedman-KienS Zolla-Pazner
Jan 1, 1980·Archives of Virology·E Buimovici-KleinL Z Cooper
Jan 1, 1971·Infection and Immunity·D ArmstrongL Steger

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Apr 15, 1996·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·D H SheppM H Kaplan

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