IgM in the kidney: a multiple personality disorder

Kidney International
Jeffrey L Platt, Marilia Cascalho

Abstract

IgM in the blood of normal individuals consists mainly of 'natural' polyreactive antibodies. Natural IgM is thought to provide an initial defense against infection and to promote the healing of wounded cells. Yet, as Panzer and colleagues show, these benefits can be eclipsed when the IgM binds to damaged cells of the glomerulus, activating complement. IgM in glomeruli thus signifies cellular damage and may warn that the pace of that damage exceeds the capacity for repair.

References

May 1, 1996·The Journal of Experimental Medicine·M R WeiserM C Carroll
Apr 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Liudmila KulikV Michael Holers
Apr 2, 2011·The Journal of Biological Chemistry·Sarah PotezEduard B Babiychuk
Jan 22, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marilia I CascalhoJeffrey L Platt
Feb 9, 2013·Journal of the American Society of Nephrology : JASN·Derek StrassheimJoshua M Thurman
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Apr 3, 2014·Journal of Clinical Immunology·Caroline Grönwall, Gregg J Silverman
May 7, 2015·Kidney International·Sarah E PanzerJoshua M Thurman

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Citations

Feb 11, 2016·Immunotherapy·Marilia Cascalho, Jeffrey L Platt
Jul 16, 2016·International Journal of Molecular Sciences·Jeffrey L PlattMarilia Cascalho
Dec 13, 2018·ILAR Journal·Jeffrey L PlattJorge A Piedrahita
Oct 15, 2019·Immunological Reviews·Jeffrey L PlattMarilia Cascalho
Jul 7, 2017·Current Opinion in Organ Transplantation·Jeffrey L PlattMarilia Cascalho
Jan 11, 2018·Transplantation·Jeffrey L Platt, Marilia Cascalho
Oct 8, 2018·Clinical and Experimental Nephrology·Cihan HeybeliTaner Çamsarı
Apr 14, 2019·Human Immunology·Jeffrey L Platt, Marilia Cascalho

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Methods Mentioned

BETA
xenografts

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