IgM myeloma: a report of four cases

Annals of Hematology
T DierlammD-K Hossfeld

Abstract

IgM myeloma is a rare disease, accounting for approximately 0.5% of multiple myelomas (MM). Here we report four cases of IgM multiple myeloma. Two were diagnosed in advanced clinical stages with multiple osteolytic lesions, leading to hypercalcemia in one patient. Bone marrow morphology showed a variable degree of infiltration with mainly mature plasma cells. An immunophenotypic analysis performed in one case showed expression of CD38 and monoclonal cytoplasmatic immunoglobulin. Interphase fluorescence in situ hybridization performed in one case did not reveal any aneuploidies or deletions of the retinoblastoma, P16, or P53 tumor suppressor genes. While one patient with a smoldering IgM myeloma did not need specific therapy, the others received cytotoxic treatment based on standard chemotherapy for MM. The outcomes were one stable disease, one sustained complete remission, and one progressive disease. All four patients were alive 1 year after diagnosis. One died due to progressive disease after 31 months. We conclude that IgM myeloma shares clinical and histological features with other MM rather than with Waldenström's macroglobulinemia, which is most commonly diagnosed in cases with IgM monoclonal gammopathy. Since MM and Wald...Continue Reading

Citations

Nov 18, 2011·Current Neurology and Neuroscience Reports·Sindhu Ramchandren, Richard A Lewis
Apr 30, 2003·Seminars in Oncology·Hervé Avet-LoiseauRégis Bataille
Apr 30, 2003·Seminars in Oncology·Roger G Owen
Sep 13, 2006·Leukemia & Lymphoma·Ombretta AnnibaliGiuseppe Avvisati
Mar 30, 2005·Clinical Lymphoma·Kartik KonduriMarvin J Stone
Jun 30, 2007·European Journal of Haematology·Paola GnerreFranco Dallegri
Apr 7, 2017·American Journal of Hematology·Jorge J CastilloMorie A Gertz
Jul 25, 2009·Current Opinion in Neurology·Sindhu Ramchandren, Richard A Lewis
Jun 1, 2005·Veterinary and Comparative Oncology·F GentiliniP Famigli Bergamini
May 15, 2010·Advances in Hematology·Toshihiko Tanno, Jeffery L Miller

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