IgY - turning the page toward passive immunization in COVID-19 infection (Review)

Experimental and Therapeutic Medicine
Carolina ConstantinDemetrios A Spandidos

Abstract

The world is facing one of the major outbreaks of viral infection of the modern history, however, as vaccine development workflow is still tedious and can not control the infection spreading, researchers are turning to passive immunization as a good and quick alternative to treat and contain the spreading. Within passive immunization domain, raising specific immunoglobulin (Ig)Y against acute respiratory tract infection has been developing for more than 20 years. Far from being an obsolete chapter we will revise the IgY-technology as a new frontier for research and clinic. A wide range of IgY applications has been effectively confirmed in both human and animal health. The molecular particularities of IgY give them functional advantages recommending them as good candidates in this endeavor. Obtaining specific IgY is sustained by reliable and nature friendly methodology as an alternative for mammalian antibodies. The aria of application is continuously enlarging from bacterial and viral infections to tumor biology. Specific anti-viral IgY were previously tested in several designs, thus its worth pointing out that in the actual COVID-19 pandemic context, respiratory infections need an enlarged arsenal of therapeutic approaches and...Continue Reading

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Citations

Sep 3, 2020·Vaccines·José M Pérez de la LastraAntonio Morales-delaNuez
Feb 5, 2021·Journal of Immunoassay & Immunochemistry·Marinela BostanCoralia Bleotu
Oct 23, 2020·Journal of Immunoassay & Immunochemistry·Monica Neagu
Nov 3, 2020·Journal of Immunology Research·Yan LuWen Wang
Dec 29, 2020·Journal of Immunoassay & Immunochemistry·Alice GrigoreRadu Albulescu
Feb 12, 2021·Journal of Biomedical Informatics·Rui ZhangHalil Kilicoglu
Mar 19, 2021·Journal of Cellular and Molecular Medicine·Monica NeaguAristidis Tsatsakis
Jun 29, 2021·Frontiers in Immunology·Lucia LeeDaria Mochly-Rosen
Jun 17, 2021·Molecular Medicine Reports·Sabina ZuracMonica Neagu
Oct 12, 2021·Nanomedicine·Carolina ConstantinMonica Neagu

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Methods Mentioned

BETA
ELISA
ELISAs
affinity purification

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