PMID: 2510583Jul 1, 1989Paper

II. Effect of n-3 and n-6 fatty acids on mammary H-ras expression and PGE2 levels in DMBA-treated rats

Anticancer Research
R A KarmaliM Modak

Abstract

In an attempt to evaluate some of the mechanisms by which dietary n-3 and n-6 PUFA influence 7,12,dimethylbenz(a)anthracene (DMBA)-induced mammary tumorigenesis, we measured: 1) concentrations of prostaglandin (PG) E1 (metabolite of C20:3, n-6) and PGE2 (metabolite of C20:4, n-6); and, 2) expression of H-ras oncogene in non-cancerous (NC) and cancerous (C) mammary tissues taken from rats 14 weeks after they were treated with 5 mg DMBA. Five groups of rats were fed one of the synthetic diets containing 23.5% of fat by weight: I. Blackcurrant oil (BCO) (23.5%); II. corn oil (CO) (23.5%); III. BCO (15.5%) + fish oil (FO) (8%); IV. FO (20.5%) + CO (3%); and V. BCO (20.5%) + FO (3%). PGE1 and PGE2 levels were lower in NC mammary tissues than in corresponding C tissues in all 5 diet groups. In Group IV, PGE2 levels in both NC and C tissues were significantly lower than in those of the remaining 4 groups. In groups fed BCO alone (I) or in combination with FO (III and V), PGE2, content in C tissue was lower compared with the corn oil-fed group (II), but these observations were significant only for III and V. Conversely, in Groups III and V, the content of PGE1 in C tissues was significantly higher. The results of the present study demo...Continue Reading

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