PMID: 9438516Jan 23, 1998Paper

II. Functional consequences of intragastrically administered ethanol in rats as measured by the 2-[14C]deoxyglucose method: the contribution of dopamine

Alcoholism, Clinical and Experimental Research
L Williams-Hemby, L J Porrino

Abstract

As outlined in the companion paper, many of the changes in functional activity produced by acute intragastric ethanol administration as determined by the quantitative autoradiographic 2-[14C]deoxyglucose method occur in structures of the mesocorticolimbic and nigrostriatal dopamine circuits. In this study, a dopaminergic antagonist, flupenthixol, was used to determine the contribution of dopamine to the ethanol-induced increases in functional activity. To assess the ability of flupenthixol to block dopaminergic-induced increases in glucose utilization, it was first examined in conjunction with the indirect dopaminergic agonist methylphenidate. Pretreatment with flupenthixol significantly reduced methylphenidate-induced increases in glucose utilization in structures of the mesocorticolimbic and nigrostriatal dopamine circuits. These findings indicate that this is an effective strategy for the determination of the neurochemical contributions to the changes in CNS functional activity. Flupenthixol pretreatment blocked many of the ethanol-induced increases in glucose utilization at the 0.25 g/kg dose, particularly in mesocorticolimbic and nigrostriatal structures. At the 1.0 and 2.0 g/kg ethanol doses, however, pretreatment with fl...Continue Reading

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Citations

Aug 18, 2001·Pharmacology, Biochemistry, and Behavior·D G SmithJ M Murphy
Feb 7, 2002·Pharmacology, Biochemistry, and Behavior·William J McBride
Sep 17, 1998·Pharmacology, Biochemistry, and Behavior·D LyonsL J Porrino
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Oct 29, 2009·Alcoholism, Clinical and Experimental Research·Eric W FishC J Malanga

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