PMID: 9438530Jan 23, 1998Paper

II: the effects of recombinant human insulin-like growth factor-1 on immunological recovery in the malnourished alcoholic rat

Alcoholism, Clinical and Experimental Research
C L MendenhallP S Gartside

Abstract

Immunological abnormalities are frequently observed in alcoholics with severe liver disease and are typically in association with immune abnormalities. Concomitantly, serum levels of insulin-like growth factor-1 (IGF-1) are frequently very low in these patients. Because IGF-1 is known to modulate both nutrition and immune status, the present study was undertaken to evaluate an in vivo rat model of alcoholism and malnutrition, the possibility of a therapeutic application for IGF-1. Controlled injury was induced by 14 days of calorie restriction and alcohol feeding that resulted in a 9% loss of body mass. Changes were compared with normal unrestricted control rats that gained 28% above their pretreatment body mass during the same period. Immunological impairment was assessed using thymus and spleen mass, cellularity and spleen T-lymphocyte function. Recovery was evaluated after 28 days of treatment using various combinations of: (1) high calorie intake, (2) cessation from alcohol feeding, and (3) IGF-1. The thymus was most severely affected, losing 52.3% of its mass and 55.7% of its cellularity. The spleen was diminished, losing 31.2% of its mass and 41.9% of its cellularity. All of the spleen T-lymphocyte subsets were diminished...Continue Reading

References

Dec 1, 1990·Gastroenterology·C L MendenhallK Lamping
Apr 1, 1989·Alcoholism, Clinical and Experimental Research·N E DehneC J Grossman
Mar 1, 1988·Digestive Diseases and Sciences·C MendenhallD D Morgan
Jan 1, 1988·International Journal of Immunopharmacology·C J GrossmanG A Roselle
Mar 1, 1974·The American Journal of Digestive Diseases·M R BerenyiD Cruz
Jan 1, 1984·The Medical Clinics of North America·H G Adams, C Jordan
Feb 1, 1994·Clinical and Experimental Immunology·K RobbinsP Jardieu
May 1, 1993·Seminars in Liver Disease·C McClainA M Diehl

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Citations

Aug 16, 2005·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·R NovosyadlyyJ-G Scharf

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