IK-guided PP2A suppresses Aurora B activity in the interphase of tumor cells

Cellular and Molecular Life Sciences : CMLS
Sunyi LeeYoung Yang

Abstract

Aurora B activation is triggered at the mitotic entry and required for proper microtubule-kinetochore attachment at mitotic phase. Therefore, Aurora B should be in inactive form in interphase to prevent aberrant cell cycle progression. However, it is unclear how the inactivation of Aurora B is sustained during interphase. In this study, we find that IK depletion-induced mitotic arrest leads to G2 arrest by Aurora B inhibition, indicating that IK depletion enhances Aurora B activation before mitotic entry. IK binds to Aurora B, and colocalizes on the nuclear foci during interphase. Our data further show that IK inhibits Aurora B activation through recruiting PP2A into IK and Aurora B complex. It is thus believed that IK, as a scaffold protein, guides PP2A into Aurora B to suppress its activity in interphase until mitotic entry.

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Citations

Apr 20, 2019·Nature Communications·Jordi Bertran-AlamilloMiguel-Angel Molina-Vila
Jul 13, 2021·Cell Biochemistry and Function·Chao GaoFengxia Xue

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