Ikaros gene expression and leukemia

Leukemia & Lymphoma
C TonnelleC Chabannon

Abstract

The Ikaros (Ik) protein, or LyF1, was initially described as a protein binding to regulatory sequences of a number of genes expressed in murine lymphoid cells. Ikaros is a critical regulator of normal hematopoietic stem cell differentiation, as evidenced by dramatic defects in the lymphoid compartments, in homozygous animals with gene inactivation. Because differential splicing produces multiple isoforms with potentially different functions, Ikaros provides a unique model to study how post-transcriptional mechanisms may be involved in neoplastic processes. Indeed, several groups including ours have underlined evidences that expression of different Ikaros isoforms vary among different types of leukemias. The predominance of short isoforms in certain subsets is intriguing. Here, additional observations reinforced the hypothesis that Ikaros expression may be deregulated in human leukemias. Whether this is a cause or a consequence of the leukemic process remains speculative. Other human diseases however, provide examples of abnormal post-transcriptional regulations that have been further characterized.

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Citations

Oct 16, 2007·Blood·Marilyne DijonCécile Tonnelle
Aug 5, 2008·Blood Cells, Molecules & Diseases·Alexander N MeleshkoTatjana V Savitskaja
Apr 12, 2011·Molecular Immunology·Liza B John, Alister C Ward
Dec 1, 2006·The Journal of Biological Chemistry·Tapani RonniSinisa Dovat
Apr 4, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Liza B JohnAlister C Ward

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