IKZF1 gene polymorphisms increased the risk of childhood acute lymphoblastic leukemia in an Iranian population

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
G BahariMohsen Taheri

Abstract

Genome-wide association studies (GWAS) have proved the association of IKZF1 polymorphisms with childhood acute lymphoblastic leukemia (ALL). In the present study, we aimed to inspect the impact of IKZF1 gene polymorphisms and childhood ALL in a sample of Iranian population who live in south east of Iran. This case-control study was done on 110 children diagnosed with ALL and 120 healthy children. The IKZF1 (rs4132601 T > G, rs11978267 A > G, rs11980379 T > C, and rs10272724 T > C) polymorphisms were determined using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). The results showed that rs4132601 T > G polymorphism increased the risk of ALL in the codominant (OR = 2.96, 95 % CI = 1.58-5.54, p = 0.0008, TG vs TT; and OR = 2.75, 95 % CI = 1.31-5.76, p = 0.0094, GG vs TT) and dominant (OR = 2.89, 95 % CI = 1.61-5.19, p = 0.0004, TG + GG vs TT) inheritance models. On the other hand, the rs4132601 G allele increased the risk of ALL (OR = 1.86, 95 % CI = 1.28-2.96; p = 0.0011) in comparison with the T allele. We have also showed that rs11980379 T > C variant increased the risk of ALL in codominant (OR = 2.43, 95 % CI = 1.28-4.60, p = 0.0076, TC vs TT; and OR = 2.35, 95 % CI = 1.14-4.85, p = 0.0291, CC v...Continue Reading

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Citations

Jan 4, 2017·Nucleosides, Nucleotides & Nucleic Acids·Ebrahim Eskandari-NasabMohsen Taheri
Aug 3, 2017·Genetic Testing and Molecular Biomarkers·Boshra Al-AbsiSekaran Muniandy
Feb 27, 2019·Current Molecular Medicine·Safaa I TayelRania S El-Zayat
May 8, 2020·Diagnostic Pathology·Majid Ghayour-MobarhanMeysam Moghbeli
Sep 15, 2017·Medical Oncology·Angela Gutierrez-CaminoAfrica García-Orad
Jan 17, 2021·Molecular Genetics & Genomic Medicine·Jorge Gutiérrez-FrancoAlejandro Vázquez-Reyes

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