IL-1 or TNF receptor gene deletion delays onset of encephalopathy and attenuates brain edema in experimental acute liver failure

Neurochemistry International
Chantal BémeurRoger F Butterworth

Abstract

Previous reports suggested that brain-derived proinflammatory cytokines are involved in the pathogenesis of hepatic encephalopathy (HE) and brain edema in acute liver failure (ALF). To further address this issue, expression of interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) mRNAs were measured in the brains of mice with acute liver failure resulting from exposure to azoxymethane. In addition, time to severe encephalopathy (coma) was assessed in mice lacking genes coding for interferon-gamma, the tumor necrosis factor receptor-1 or the interleukin-1 type 1 receptor. Interleukin-1beta, tumor necrosis factor-alpha and interferon-gamma expression were quantified using RT-PCR. Significant increases in interleukin-1beta and tumor necrosis factor-alpha mRNA were observed in the frontal cortex of azoxymethane-treated wild-type mice at coma stages of encephalopathy. Interferon-gamma, however, could not be detected in the brains of these animals. Onset of severe encephalopathy (coma) and brain edema in ALF mice were significantly delayed in interleukin-1 type 1 receptor or tumor necrosis factor receptor-1 knockout mice. Deletion of the interferon-gamma gene, on the other hand, had no...Continue Reading

References

Oct 1, 1978·Journal of Neurosurgery·A MarmarouH Bhagavan
Jun 25, 1985·Nucleic Acids Research·L FransenA Van Vliet
Mar 25, 1986·Nucleic Acids Research·K TokunagaS Sakiyama
Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·P W Gray, D V Goeddel
Nov 9, 2002·Alimentary Pharmacology & Therapeutics·S SenR Jalan
Mar 28, 2006·Neurochemistry International·Mireille BélangerRoger F Butterworth
Sep 22, 2007·Neurochemistry International·Jessy J AlexanderRichard J Quigg
Mar 5, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Wenlei JiangRoger F Butterworth

❮ Previous
Next ❯

Citations

Mar 16, 2013·Cell Biochemistry and Biophysics·Zhongyang DingGuorong Huang
Oct 15, 2010·Journal of Neuroinflammation·Kakulavarapu V Rama RaoMichael D Norenberg
Jul 16, 2010·World Journal of Gastroenterology : WJG·Amit S SeyanDebbie L Shawcross
Jun 14, 2013·Gastroenterology Research and Practice·Wei CuiPei Liu
Jul 20, 2014·International Immunopharmacology·Lei GuHong Zhou
Jan 14, 2012·Journal of the Chinese Medical Association : JCMA·I-Fang HsinShou-Dong Lee
Dec 20, 2015·The American Journal of Pathology·Matthew McMillinSharon DeMorrow
Feb 5, 2013·Neurochemistry International·Cristina R Bosoi, Christopher F Rose
Nov 28, 2012·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Abedin VakiliAhmad Reza Bandegi
Oct 23, 2012·Clinics and Research in Hepatology and Gastroenterology·Ming LuoWu-Kui Cao
Dec 27, 2011·Neurochemistry International·Kiran K ThumburuRadha K Dhiman
Jan 31, 2012·Neurochemistry International·Kakulavarapu V Rama RaoMichael D Norenberg
Nov 22, 2011·Neurochemistry International·Justin H Nguyen
Nov 2, 2011·Neurochemistry International·Samir AhbouchaGlen Baker
Aug 26, 2011·Neurochemistry International·Roger F Butterworth
Nov 23, 2010·Neurobiology of Disease·A R JayakumarM D Norenberg
Sep 4, 2010·Pharmacology & Therapeutics·Ian A ClarkBryce Vissel
Jul 29, 2015·Clinics and Research in Hepatology and Gastroenterology·Ming LuoFei-Hu Bai
Apr 1, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Irina ZemtsovaDieter Häussinger
Apr 12, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Roger F Butterworth
Jun 1, 2012·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Ming LuoWu-Kui Cao
Dec 14, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Gavin WrightRajiv Jalan
Apr 12, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Feng ChenJustin H Nguyen
Aug 6, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Anne ChastreRoger F Butterworth
Jul 17, 2015·Journal of Neurochemistry·Matthew McMillinSharon DeMorrow
Jun 5, 2015·Journal of Clinical and Experimental Hepatology·Dominic R AldridgeDebbie L Shawcross
May 29, 2012·Journal of Hepatology·Gyongyi Szabo, Timea Csak
Jun 5, 2015·Journal of Clinical and Experimental Hepatology·Roger F Butterworth
Jun 5, 2015·Journal of Clinical and Experimental Hepatology·Arumugam R JayakumarMichael D Norenberg
Aug 27, 2016·Journal of Neuroinflammation·Matthew McMillinSharon DeMorrow
Aug 24, 2010·Arquivos de neuro-psiquiatria·Aline Silva de MirandaAntônio Lúcio Teixeira
Jul 3, 2013·Nature Reviews. Gastroenterology & Hepatology·Roger F Butterworth
Aug 12, 2014·American Journal of Physiology. Gastrointestinal and Liver Physiology·Dušan MladenovićOlivera Stanojlović
Mar 9, 2020·Metabolic Brain Disease·Ali SepehrinezhadRoger Williams
Mar 2, 2019·World Journal of Hepatology·Luiza Cioglia Dias LimaAna Cristina Simões E Silva

❮ Previous
Next ❯

Related Concepts

Related Feeds

Related Papers

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Wenlei JiangRoger F Butterworth
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Roger F Butterworth
© 2022 Meta ULC. All rights reserved