IL-1 type I receptor mediates acute phase response to turpentine, but not lipopolysaccharide, in mice

The American Journal of Physiology
L R LeonM J Kluger

Abstract

This study examined the role of the interleukin-1 (IL-1) type I receptor (IL-1RtI) in the acute phase response (APR) to inflammation in mice. Turpentine (100 microliters/mouse) injected subcutaneously induced fever, lethargy, body weight loss, and anorexia in IL-1RtI wild-type mice. Knockout mice lacking the IL-1RtI were resistant to these effects of turpentine, supporting a role for this receptor in the APR to local inflammation. The intraperitoneal injection of a low (50 micrograms/kg) or high (2.5 mg/kg) dose of lipopolysaccharide (LPS) induced similar APRs in IL-1RtI wild-type and knockout mice. IL-1RtI knockout mice were resistant to the APR induced by peripherally injected murine IL-1 beta, suggesting that it is not the interaction of endogenous IL-1 beta with IL-1RtII that induces an APR to LPS in these mice. We speculate that the absence of IL-1RtI in these knockout mice results in the sensitization of other cytokine pathways to mediate the APR to LPS.

Citations

Jan 3, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·J G MorelandD A Schwartz
Jun 19, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Alexander V GourineMatthew J Kluger
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