Abstract
Chronic intraprostatic inflammation is suspected to play a major role in the pathogenesis of prostate cancer (PCa). Polymorphisms in interleukin-10 (IL-10), a key anti-inflammatory cytokine gene can influence immune response and immune evasion of tumor cells. Its role as an anti-metastatic molecule is also well documented. Gene promoter polymorphisms in IL-10 (-1082 G>A and -819 C>T) was analyzed in 159 PCa patients and 259 healthy controls to investigate their potential association with susceptibility for PCa. Our results indicated that the heterozygous (GA) and homozygous mutant (AA) genotypes of IL-10 -1082 to be more prevalent among PCa patients in comparison to controls (GA: OR - 2.8, p = 0.011; AA: OR - 2.3, p = 0.037). More patients (92.5%) than controls (82.7%) were positive for the A allele (GA + AA: OR - 2.6, p = 0.015). We observed lower frequency of T(-819)-G(-1082) haplotype in patients without bone metastasis (4.4%, OR - 0.30, p = 0.019) in comparison to PCa patients with bone metastasis (12.6%). Our results support the emerging hypothesis that genetically determined immune activity may play a role in the pathophysiology of PCa. Our findings of high producer of IL-10 -1082 variants suggest initiation of PCa. Futur...Continue Reading
References
Jan 1, 1992·International Archives of Allergy and Immunology·H Spits, R de Waal Malefyt
Nov 1, 1991·The Journal of Experimental Medicine·R de Waal MalefytJ E de Vries
Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Jan 1, 1974·The Journal of Urology·D F Gleason, G T Mellinger
Apr 1, 1995·The Journal of Allergy and Clinical Immunology·C J MeliskaJ M Martinko
Jun 24, 1996·Cancer Letters·C FortisM Braga
Aug 1, 1996·The Journal of Experimental Medicine·L M ZhengI King
Feb 1, 1997·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·D M TurnerI V Hutchinson
Mar 10, 1999·Journal of the National Cancer Institute·L N KolonelR V Cooney
Nov 2, 1999·Transplant Immunology·C PerreyI V Hutchinson
Jul 13, 2000·The New England Journal of Medicine·P LichtensteinK Hemminki
Aug 22, 2000·The Prostate·X FilellaA M Ballesta
Mar 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A W GibsonR P Kimberly
Oct 9, 2001·Epidemiologic Reviews·K HickeyA Green
Oct 9, 2001·Epidemiologic Reviews·R B Hayes
Jan 30, 2004·Cytokine & Growth Factor Reviews·Simone MocellinMario Lise
Mar 5, 2004·Cancer Research·Benjamin SredniYona Kalechman
Nov 9, 2004·Advances in Cancer Research·Li Yang, David P Carbone
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani
Dec 22, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Tanja EderKarin S Kapp
Mar 27, 2007·Nature Reviews. Cancer·Angelo M De MarzoWilliam G Nelson
Nov 14, 2007·Cancer Causes & Control : CCC·Jessica M Faupel-BadgerJoseph A Tangrea
Aug 1, 2008·Archives of Toxicology·Pravin KesarwaniRama Devi Mittal
Citations
Feb 23, 2011·Prostate Cancer and Prostatic Diseases·N ShaoL-x Hua
Apr 12, 2013·Omics : a Journal of Integrative Biology·Zhibin YuGuiyuan Li
Apr 24, 2012·Carcinogenesis·Ernest K AmankwahJong Y Park
Aug 26, 2010·BMC Cancer·Jie LiuZhehai Wang
Dec 24, 2013·Hereditary Cancer in Clinical Practice·Dominique Z JonesLacreis R Kidd
May 31, 2012·Familial Cancer·Kui ZhangLin Zhang
Jan 8, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Yan-Feng ZouFen Huang
Sep 19, 2015·Meta Gene·Sushil KumarUday C Ghoshal
Oct 11, 2012·Cytokine·Qi DingJing Wang
Jan 1, 2010·Cancers·Elizabeth A TindallDesiree C Petersen
Oct 11, 2017·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Kapil BandilMausumi Bharadwaj
May 21, 2017·Oncotarget·Tingting MenGeng Tian
Oct 17, 2017·Oncotarget·Hao ChenKewei Ren
Dec 21, 2016·SpringerPlus·Xiaohan ShiShangwei Li
Apr 26, 2014·Oncology Letters·Jian ZhouLi-Ming Lu
Feb 9, 2012·Molecular Biology Reports·Feng PanYing Zhang
May 3, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Preetiner Pal SinghAparajita Khatri