Sep 15, 2018

IL-10 and ICOS differentially regulate T cell responses in the brain during chronic Toxoplasma gondii infection

bioRxiv
Carleigh Anne O'BrienTajie Harris

Abstract

Control of chronic CNS infection with the parasite Toxoplasma gondii requires an ongoing T cell response in the brain. Immunosuppressive cytokines are also important for preventing lethal immunopathology during chronic infection. To explore the loss of suppressive cytokine exclusively during the chronic phase of infection we blocked IL-10 receptor (IL-10R). Blockade was associated with widespread changes in the inflammatory response, including increased antigen presenting cell (APC) activation, expansion of CD4+ T cells, and increased neutrophil recruitment to the brain, consistent with previous reports. We then sought to identify regulatory mechanisms contributing to IL-10 production, focusing on ICOS (inducible T cell costimulator), a molecule that promotes IL-10 production in many systems. Unexpectedly, ICOS-ligand (ICOSL) blockade led to a local expansion of effector T cells in the inflamed brain without affecting IL-10 production or APC activation. Instead, we found that ICOSL blockade led to changes in T cells associated with their proliferation and survival. Specifically, we observed increased expression of IL-2 associated signaling molecules, including CD25, STAT5 phosphorylation, Ki67, and Bcl-2 in T cells in the brain...Continue Reading

  • References
  • Citations

References

  • We're still populating references for this paper, please check back later.
  • References
  • Citations

Citations

  • This paper may not have been cited yet.

Mentioned in this Paper

Physicians - Immunopathology
IL2RA protein, human
Immunopathology Specialty
ICOSLG gene
T-Lymphocyte
Activation of T Cell Antigen Processing and Presentation
Antigen-Presenting Cells
Recombinant Interleukin-10
IL2
ICOSLG

Related Feeds

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

Related Papers

The Journal of Immunology : Official Journal of the American Association of Immunologists
Carleigh Anne O'BrienTajie Harris
The Journal of Immunology : Official Journal of the American Association of Immunologists
Eric N VillegasChristopher A Hunter
Proceedings of the National Academy of Sciences of the United States of America
Saman KhayyamianHans W Mages
Immunology Letters
Miranda E A T van Berkel, Mariëtte A Oosterwegel
Transplantation Proceedings
N O S CâmaraR I Lechler
© 2020 Meta ULC. All rights reserved