IL-10 and IL-22 in Mucosal Immunity: Driving Protection and Pathology.

Frontiers in Immunology
Hua-Xing WeiBofeng Li

Abstract

The barrier surfaces of the gastrointestinal tract are in constant contact with various microorganisms. Cytokines orchestrate the mucosal adaptive and innate immune cells in the defense against pathogens. IL-10 and IL-22 are the best studied members of the IL-10 family and play essential roles in maintaining mucosal homeostasis. IL-10 serves as an important regulator in preventing pro-inflammatory responses while IL-22 plays a protective role in tissue damage and contributes to pathology in certain settings. In this review, we focus on these two cytokines in the development of gastrointestinal diseases, including inflammatory bowel diseases (IBD) and colitis-associated cancer (CAC). We summarize the recent studies and try to gain a better understanding on how they regulate immune responses to maintain equilibrium under inflammatory conditions.

References

Dec 1, 1989·The Journal of Experimental Medicine·D F FiorentinoT R Mosmann
Apr 1, 1994·European Journal of Immunology·F WillemsM Goldman
Mar 1, 1994·International Journal of Cancer. Journal International Du Cancer·Q ChenP Hersey
Mar 28, 1998·The Journal of Experimental Medicine·S D SpencerM Aguet
May 30, 1998·Scandinavian Journal of Gastroenterology·M TomoyoseK Tanikawa
Feb 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·L DumoutierJ C Renauld
Jun 2, 2000·Gastroenterology·K L MadsenR N Fedorak
Jul 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·E M BenkhartH W Ziegler-Heitbrock
Aug 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·F N LauwT van der Poll
Aug 24, 2000·Proceedings of the National Academy of Sciences of the United States of America·L DumoutierJ C Renauld
Feb 24, 2001·Genes and Immunity·L DumoutierJ C Renauld
May 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kerstin WolkRobert Sabat
Jan 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yaozhong DingJonathan S Bromberg
Jul 9, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yi-Wen LiuWen-Chang Chang
Mar 23, 2004·Annual Review of Immunology·Sidney PestkaPaul B Fisher
Aug 17, 2004·Immunity·Kerstin WolkRobert Sabat
Oct 13, 2004·FEMS Microbiology Letters·Anderson MiyoshiVasco Azevedo
Mar 7, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·John ShoemakerAnne O'Garra
Mar 16, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Stephan BrandJulia Dambacher
Mar 28, 2006·Nature Immunology·Axel KalliesStephen L Nutt
Jul 13, 2006·The Journal of Biological Chemistry·Shanjin CaoDavid M Mosser
Jan 4, 2008·The Journal of Clinical Investigation·Ken SugimotoAtsushi Mizoguchi
Jul 5, 2008·Structure·Brandi C JonesMark R Walter
Jul 11, 2008·Immunological Reviews·Anne O'GarraCatherine Hawrylowicz
Dec 23, 2008·Immunity·Lauren A ZenewiczRichard A Flavell

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BETA
biopsy
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Clinical Trials Mentioned

NCT02847052

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